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Literature summary extracted from

  • Soulsby, M.D.; Wojcikiewicz, R.J.H.
    The type III inositol 1,4,5-trisphosphate receptor is phosphorylated by cAMP-dependent protein kinase at three sites (2005), Biochem. J., 392, 493-497.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.11 8-bromo-cAMP activates Homo sapiens
2.7.11.11 additional information forskolin induces enzyme activity Homo sapiens
2.7.11.11 prostaglandin E1 activates Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.11 Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.11 ATP + type III inositol 1,4,5-trisphosphate receptor Homo sapiens i.e. IP3 receptor, recombinantly expressed in HEK cells, forms tetrameric Ca2+ channels in the endoplasmic reticulum ADP + phosphorylated type III inositol 1,4,5-trisphosphate receptor
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.11 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.11 HEK-293 cell embryonic kidney cell Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.11 ATP + type III inositol 1,4,5-trisphosphate receptor i.e. IP3 receptor, recombinantly expressed in HEK cells, forms tetrameric Ca2+ channels in the endoplasmic reticulum Homo sapiens ADP + phosphorylated type III inositol 1,4,5-trisphosphate receptor
-
 ?
2.7.11.11 ATP + type III inositol 1,4,5-trisphosphate receptor phosphorylation sites are Ser916, Ser934, and Ser1832, Ser934 is the most susceptible site Homo sapiens ADP + phosphorylated type III inositol 1,4,5-trisphosphate receptor
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.11 PKA
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.11 30
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.11 ATP
-
 Homo sapiens