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Literature summary extracted from

  • Liu, J.; Chang, C.C.; Westover, E.J.; Covey, D.F.; Chang, T.Y.
    Investigating the allosterism of acyl coenzyme A: cholesterol acyltransferase (ACAT) by using various sterols: in vitro and intact cell studies (2005), Biochem. J., 391, 389-397.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.26 cholesterol presence of cholesterol stimulates reaction of ACAT1 with sitosterol up to 3fold, reaction of ACAT2 is only moderately activated Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.26 Homo sapiens
-
 recombinant isoforms ACAT1 and ACAT2 with His-tag each
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.26 additional information stereochemistry of 3-hydroxyl group at steroid ring is a critical structural feature for ACAT1 isoform Homo sapiens ?
-
 ?
2.3.1.26 oleoyl-CoA + cholesterol
-
 Homo sapiens CoA + cholesteryl oleate
-
 ?
2.3.1.26 oleoyl-CoA + sitosterol
-
 Homo sapiens CoA + sitosteryl oleate
-
 ?