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Literature summary extracted from

  • Ryan, A.J.; Fisher, K.; Thomas, C.P.; Mallampalli, R.K.
    Transcriptional repression of the CTP:phosphocholine cytidylyltransferase gene by sphingosine (2004), Biochem. J., 382, 741-750.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.7.15 glucosylceramide
-
 Mus musculus
2.7.7.15 glucosylceramide
-
 Rattus norvegicus
2.7.7.15 Lipids regulation of activity by reversible association with membrane lipids Mus musculus
2.7.7.15 Lipids regulation of activity by reversible association with membrane lipids Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.15 expressed in mice Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.15 ceramide
-
 Mus musculus
2.7.7.15 ceramide
-
 Rattus norvegicus
2.7.7.15 lysophosphatidylcholine
-
 Mus musculus
2.7.7.15 lysophosphatidylcholine
-
 Rattus norvegicus
2.7.7.15 sphingosine sphingosine decreases CCTalpha protein and mRNA level Mus musculus
2.7.7.15 sphingosine sphingosine decreases CCTalpha protein and mRNA level Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.15 cytosol
-
 Mus musculus 5829
-
2.7.7.15 cytosol
-
 Rattus norvegicus 5829
-
2.7.7.15 endoplasmic reticulum
-
 Mus musculus 5783
-
2.7.7.15 endoplasmic reticulum
-
 Rattus norvegicus 5783
-
2.7.7.15 membrane enzyme is activated when bound to vesicles Mus musculus 16020
-
2.7.7.15 membrane enzyme is activated when bound to vesicles Rattus norvegicus 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.15 CTP + choline phosphate Mus musculus rate limiting enzyme for the synthesis of phosphatidylcholine diphosphate + CDP-choline
-
 ?
2.7.7.15 CTP + choline phosphate Rattus norvegicus rate limiting enzyme for the synthesis of phosphatidylcholine diphosphate + CDP-choline
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.15 Mus musculus
-
-
-
2.7.7.15 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.7.15 phosphoprotein enzyme phosphorylation is involved in regulation of activity Mus musculus
2.7.7.15 phosphoprotein enzyme phosphorylation is involved in regulation of activity Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.15 lung alveolar type II epithelial cells Rattus norvegicus
-
2.7.7.15 lung type II epithelia Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.15 CTP + choline phosphate
-
 Mus musculus diphosphate + CDP-choline
-
 ?
2.7.7.15 CTP + choline phosphate
-
 Rattus norvegicus diphosphate + CDP-choline
-
 ?
2.7.7.15 CTP + choline phosphate rate limiting enzyme for the synthesis of phosphatidylcholine Mus musculus diphosphate + CDP-choline
-
 ?
2.7.7.15 CTP + choline phosphate rate limiting enzyme for the synthesis of phosphatidylcholine Rattus norvegicus diphosphate + CDP-choline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.15 CCTalpha
-
 Mus musculus
2.7.7.15 CCTalpha
-
 Rattus norvegicus