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Literature summary extracted from

  • Henriksson, M.L.; Sundin, C.; Jansson, A.L.; Forsberg, A.; Palmer, R.H.; Hallberg, B.
    Exoenzyme S shows selective ADP-ribosylation and GTPase-activating protein (GAP) activities towards small GTPases in vivo (2002), Biochem. J., 367, 617-628.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-acceptor Pseudomonas aeruginosa ExoS can modify multiple GTPases of the Ras superfamily in vivo. ExoS modulates the activity of several of GTP-binding proteins, such as Ras, Rap1, Rap2, Ral, Rac1, RhoA and Cdc42. It is suggested that ExoS is the major ADP-ribosyltransferase protein modulating small GTPase function encoded by Pseudomonas aeruginosa nicotinamide + (ADP-D-ribosyl)n+1-acceptor
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.30 Pseudomonas aeruginosa
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-
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-acceptor
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 Pseudomonas aeruginosa nicotinamide + (ADP-D-ribosyl)n+1-acceptor
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 ?
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-acceptor ExoS can modify multiple GTPases of the Ras superfamily in vivo. ExoS modulates the activity of several of GTP-binding proteins, such as Ras, Rap1, Rap2, Ral, Rac1, RhoA and Cdc42. It is suggested that ExoS is the major ADP-ribosyltransferase protein modulating small GTPase function encoded by Pseudomonas aeruginosa Pseudomonas aeruginosa nicotinamide + (ADP-D-ribosyl)n+1-acceptor
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 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.30 exoenzyme S
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 Pseudomonas aeruginosa
2.4.2.30 ExoS
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 Pseudomonas aeruginosa