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Literature summary extracted from

  • Crljen, V.; Volinia, S.; Banfic, H.
    Hepatocyte growth factor activates phosphoinositide 3-kinase C2beta in renal brush-border plasma membranes (2002), Biochem. J., 365, 791-799.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.154 A23187 Ca2+-ionophore, activates enzyme form PI3K-C2beta, mimicks hepatocyte growth factor HGF Rattus norvegicus
2.7.1.154 hepatocyte growth factor HGF in renal brush-border and basal lateral plasma membranes, in the latter case mediated by calpain Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.154 1,2-bis-(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid i.e. BAPTA-AM, a cell-penetrating Ca2+-chelator Rattus norvegicus
2.7.1.154 calpeptin inhibits proteolytic activation of enzyme form PI3K C2beta in brush border plasma membranes Rattus norvegicus
2.7.1.154 Wortmannin phosphoinositide 3-kinase C2beta Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.154 plasma membrane renal brush-border and basal lateral, enzyme form phosphoinositide 3-kinase C2beta occurs only in renal brush-border plasma membrane Rattus norvegicus 5886
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.154 Ca2+
-
Rattus norvegicus
2.7.1.154 Mg2+
-
Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.154 180000
-
x * 180000, enzyme form PI3K C2beta, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.154 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate Rattus norvegicus
-
ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.154 Rattus norvegicus
-
class II enzyme
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.1.154 proteolytic modification activation of enzyme form PI3K C2beta occurs probably via proteolysis in the brush broder plasma membrane Rattus norvegicus

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.154 partially by subcellular fractionation of renal cortex, plasma membrane preparation Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.154 kidney
-
Rattus norvegicus
-
2.7.1.154 renal cortex
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.154 additional information
-
-
Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.154 ATP + 1-phosphatidyl-1D-myo-inositol preferred substrate of enzyme form PI3K-C2beta Rattus norvegicus ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
?
2.7.1.154 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
Rattus norvegicus ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
-
?

Subunits

EC Number Subunits Comment Organism
2.7.1.154 ? x * 180000, enzyme form PI3K C2beta, SDS-PAGE Rattus norvegicus
2.7.1.154 More class II PI3K enzymes are distinguished from other PI3K isoenzymes by the presence of two tandem domains at their C-termini, the first one is termed a Phox homology domain, which is revealed as a novel phosphoinositide-binding domain, whereas the second is the C2 domain, which is a phospholipid-binding domain that can confer Ca2+ sensitivity Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
2.7.1.154 phosphoinositide 3-kinase
-
Rattus norvegicus
2.7.1.154 phosphoinositide 3-kinase C2beta
-
Rattus norvegicus
2.7.1.154 PI3K
-
Rattus norvegicus