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Literature summary extracted from

  • Chang, S.C.; Majerus, P.W.
    Inositol polyphosphate multikinase regulates inositol 1,4,5,6-tetrakisphosphate (2006), Biochem. Biophys. Res. Commun., 339, 209-216.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.151 expression in enzyme-deficient yeast cells, stable overexpression in HEK-293 cells, abrogates the in vivo elevation of 1D-myo-inositol 1,4,5,6-tetrakisphosphate from the Salmonella dublin SopB protein Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.151 0.00011
-
 1D-myo-inositol 1,4,5-trisphosphate recombinant enzyme, pH 7.2, 37°C Homo sapiens
2.7.1.151 0.000112
-
 inositol (1,4,5)-trisphosphate 37°C, pH 7.2 Homo sapiens
2.7.1.151 0.000129
-
 inositol (1,3,4,5)-tetrakisphosphate 37°C, pH 7.2 Homo sapiens
2.7.1.151 0.00013
-
 1D-myo-inositol 1,3,4,5-tetrakisphosphate recombinant enzyme, pH 7.2, 37°C Homo sapiens
2.7.1.151 0.00022
-
 1D-myo-inositol 1,4,5,6-tetrakisphosphate recombinant enzyme, pH 7.2, 37°C Homo sapiens
2.7.1.151 0.000222
-
 1D-myo-inositol-1,4,5,6-tetrakisphosphate 37°C, pH 7.2 Homo sapiens
2.7.1.151 0.000295
-
 inositol (1,3,4,6)-tetrakisphosphate 37°C, pH 7.2 Homo sapiens
2.7.1.151 0.0003
-
 1D-myo-inositol 1,3,4,6-tetrakisphosphate recombinant enzyme, pH 7.2, 37°C Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.151 K+
-
 Homo sapiens
2.7.1.151 Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.151 ATP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate Homo sapiens
-
 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
2.7.1.151 ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate Homo sapiens recombinant enzyme in yeast mutant cells ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
2.7.1.151 ATP + inositol 1,4,5,6-tetrakisphosphate Homo sapiens stable over-expression of the human protein in HEK-293 cells abrogates the in vivo elevation of inositol 1,4,5,6-tetrakisphosphate from the Salmonella dublin SopB protein. The enzyme may play a role in regulation of the level of inositol 1,4,5,6-tetrakisphosphate in human cells ADP + inositol (1,3,4,5,6)-pentakisphosphate
-
 ?
2.7.1.151 additional information Homo sapiens the enzyme regulates inositol 1,4,5,6-tetrakisphosphate ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.151 Homo sapiens
-
-
-
2.7.1.151 Homo sapiens
-
 recombinant
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.151 additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.151 ATP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate low activity Homo sapiens ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
2.7.1.151 ATP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate
-
 Homo sapiens ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
2.7.1.151 ATP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate preferred substrate Homo sapiens ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
2.7.1.151 ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
-
 Homo sapiens ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
2.7.1.151 ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate recombinant enzyme in yeast mutant cells Homo sapiens ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
2.7.1.151 ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
 Homo sapiens ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
2.7.1.151 ATP + inositol 1,3,4,5-tetrakisphosphate substrate preference for inositol 1,3,4,6-tetrakisphosphate over inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate Homo sapiens ADP + inositol (1,3,4,5,6)-pentakisphosphate
-
 ?
2.7.1.151 ATP + inositol 1,4,5,6-tetrakisphosphate
-
 Homo sapiens ADP + inositol (1,3,4,5,6)-pentakisphosphate
-
 ?
2.7.1.151 ATP + inositol 1,4,5,6-tetrakisphosphate stable over-expression of the human protein in HEK-293 cells abrogates the in vivo elevation of inositol 1,4,5,6-tetrakisphosphate from the Salmonella dublin SopB protein. The enzyme may play a role in regulation of the level of inositol 1,4,5,6-tetrakisphosphate in human cells Homo sapiens ADP + inositol (1,3,4,5,6)-pentakisphosphate
-
 ?
2.7.1.151 ATP + inositol 1,4,5-trisphosphate substrate preference for inositol 1,3,4,6-tetrakisphosphate over inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate Homo sapiens ADP + inositol (1,3,4,5)-tetrakisphosphate
-
 ?
2.7.1.151 inositol (1,3,4,6)-tetrakisphosphate + ATP substrate preference for inositol 1,3,4,6-tetrakisphosphate over inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate Homo sapiens ADP + inositol (1,3,4,5,6)-pentakisphosphate
-
 ?
2.7.1.151 additional information the enzyme regulates inositol 1,4,5,6-tetrakisphosphate Homo sapiens ?
-
 ?
2.7.1.151 additional information substrate specificity model, the enzyme shows inositol phosphate 5-kinase activity, overview Homo sapiens ?
-
 ?
2.7.1.151 additional information enzyme has a preferred 5-kinase activity over 3-kinase and 6-kinase activities Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.151 5-kinase
-
 Homo sapiens
2.7.1.151 inositol phosphate multikinase
-
 Homo sapiens
2.7.1.151 inositol polyphosphate multikinase
-
 Homo sapiens
2.7.1.151 IPMK
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.1.151 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.151 7.2
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.151 ATP
-
 Homo sapiens