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Literature summary extracted from

  • Roskoski, R.Jr.
    Signaling by Kit protein-tyrosine kinase - the stem cell factor receptor (2005), Biochem. Biophys. Res. Commun., 337, 1-13.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.10.1 stem cell factor soluble and membrane-bound glycoprotein, activating ligand of the stem cell receptor i.e. the Kit protein-tyrosine kinase Mus musculus
2.7.10.1 stem cell factor soluble and membrane-bound glycoprotein, activating ligand of the stem cell receptor i.e. the Kit protein-tyrosine kinase, stem cell factor ligand binding induces receptor dimerization and tyrosine kinase activation Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.10.1 expression in HEK293 cells, co-expression with different proteins interacting with the Kit receptor Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.10.1 additional information gain-of-function mutations of Kit receptor are associated with several neoplasms including acute myelogenous leukemia, gastrointestinal stromal tumors, and mastocytomas Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.10.1 additional information proto-oncogene Cbl binds to Kit and is activated by parallel binding of adaptor protein APS leading to inactivation and degradation of the Kit receptor Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.10.1 membrane
-
 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.10.1 ATP + a [protein]-L-tyrosine Mus musculus stem cell factor and Kit receptor are essential playing important roles in gametogenesis, hematopoiesis, mast cell development and function, and melanogenesis, complete absence is lethal, enzyme deficiencies lead to defects in white and red blood cell production, to hypopigmentation, and to sterility ADP + a [protein]-L-tyrosine phosphate
-
 ?
2.7.10.1 ATP + a [protein]-L-tyrosine Homo sapiens stem cell factor and Kit receptor are essential playing important roles in gametogenesis, hematopoiesis, mast cell development and function, and melanogenesis, complete absence is lethal, enzyme deficiencies lead to defects in white and red blood cell production, to hypopigmentation, and to sterility, Kit receptor signaling regulation by autophosphorylation and dephosphorylation via a phosphatase ADP + a [protein]-L-tyrosine phosphate
-
 ?
2.7.10.1 additional information Homo sapiens the activated, tyrosine-phosphorylated Kit receptor is a docking site for signal transduction molecules containing SH2 domains, diverse proteins bind to the different tyrosine phosphates of the receptor, e.g. the adaptor protein APS, Src family kinases, Shp2 tyrosyl phosphatase, adaptor proteins Grb2 and Grb7, phosphatidylinositol 3-kinase, and the adaptor protein Shc, analysis of interactions, functions, and biological effects, binding of APS leads to Kit degradation, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.1 Homo sapiens
-
-
-
2.7.10.1 Mus musculus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.10.1 phosphoprotein tyrosine autophosphorylation of the Kit receptor activated by stem cell factor ligand binding and subsequent dimerization, tyrosine phosphorylation at Tyr568, Tyr570, Tyr703, Tyr721, Tyr730, Tyr900, and Tyr936, Kit receptor signaling regulation by autophosphorylation and dephosphorylation via a phosphatase Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.10.1 embryo
-
 Mus musculus
-
2.7.10.1 embryo
-
 Homo sapiens
-
2.7.10.1 embryonic stem cell
-
 Mus musculus
-
2.7.10.1 embryonic stem cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.10.1 ATP + a [protein]-L-tyrosine
-
 Mus musculus ADP + a [protein]-L-tyrosine phosphate
-
 ?
2.7.10.1 ATP + a [protein]-L-tyrosine
-
 Homo sapiens ADP + a [protein]-L-tyrosine phosphate
-
 ?
2.7.10.1 ATP + a [protein]-L-tyrosine stem cell factor and Kit receptor are essential playing important roles in gametogenesis, hematopoiesis, mast cell development and function, and melanogenesis, complete absence is lethal, enzyme deficiencies lead to defects in white and red blood cell production, to hypopigmentation, and to sterility Mus musculus ADP + a [protein]-L-tyrosine phosphate
-
 ?
2.7.10.1 ATP + a [protein]-L-tyrosine stem cell factor and Kit receptor are essential playing important roles in gametogenesis, hematopoiesis, mast cell development and function, and melanogenesis, complete absence is lethal, enzyme deficiencies lead to defects in white and red blood cell production, to hypopigmentation, and to sterility, Kit receptor signaling regulation by autophosphorylation and dephosphorylation via a phosphatase Homo sapiens ADP + a [protein]-L-tyrosine phosphate
-
 ?
2.7.10.1 additional information the activated, tyrosine-phosphorylated Kit receptor is a docking site for signal transduction molecules containing SH2 domains, diverse proteins bind to the different tyrosine phosphates of the receptor, e.g. the adaptor protein APS, Src family kinases, Shp2 tyrosyl phosphatase, adaptor proteins Grb2 and Grb7, phosphatidylinositol 3-kinase, and the adaptor protein Shc, analysis of interactions, functions, and biological effects, binding of APS leads to Kit degradation, overview Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.10.1 dimer activated Kit receptor Homo sapiens
2.7.10.1 More the Kit receptor consists of an extracellular domain, a transmembrane segment, a juxtamembrane segment, and a protein kinase domain with an insert of about 80 amino acid residues, stem cell factor ligand binding induces receptor dimerization and tyrosine kinase activation Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.7.10.1 Kit protein-tyrosine kinase
-
 Mus musculus
2.7.10.1 Kit protein-tyrosine kinase
-
 Homo sapiens
2.7.10.1 More Kit receptor is a type III protein-tyrosine kinase Homo sapiens
2.7.10.1 stem cell receptor
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.10.1 ATP
-
 Mus musculus
2.7.10.1 ATP
-
 Homo sapiens