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Literature summary extracted from

  • Miyashiro, M.; Furuya, S.; Fujishige, K.; Sugita, T.
    Highly sensitive cell-based assay system to monitor the sialyl Lewis X biosynthesis mediated by alpha1-3 fucosyltransferase-VII (2004), Biochem. Biophys. Res. Commun., 324, 98-107.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.214 gene FUT7, stable expression in MOLT-4 8H cells being induced by the recombinant enzyme in presence of mifepristone to produce sL2x epitopes, expression of Staphylococcus aureus protein A-human FucT-VII fusion protein in Spodoptera frugiperda Sf21 insect cells via the baculovirus infection system Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.214 panosialin K specific inhibition of FucT-VII Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.214 Mn2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.214 additional information Homo sapiens sialyl Lewis X biosynthesis is mediated by alpha1-3 fucosyltransferase-VIIS, the enzyme is essential for biosynthesis of P- and E-selectin binding ligands in T-cells ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.214 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.214 T-lymphoblastoma cell
-
 Homo sapiens
-
2.4.1.214 T-lymphocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.214 GDP-beta-fucose + fetuin
-
 Homo sapiens GDP + fucosylated fetuin
-
 ?
2.4.1.214 additional information sialyl Lewis X biosynthesis is mediated by alpha1-3 fucosyltransferase-VIIS, the enzyme is essential for biosynthesis of P- and E-selectin binding ligands in T-cells Homo sapiens ?
-
 ?
2.4.1.214 additional information development of a sensitive cell-based assay system to monitor FucT-VII mediated sialyl Lewis biosynthesis Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.214 alpha1-3 fucosyltransferase-VII
-
 Homo sapiens
2.4.1.214 FucT-VII
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.214 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.214 7
-
 assay at Homo sapiens