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Literature summary extracted from

  • Carre, A.; Graf, C.; Stora, S.; Mechtcheriakova, D.; Csonga, R.; Urtz, N.; Billich, A.; Baumruker, T.; Bornancin, F.
    Ceramide kinase targeting and activity determined by its N-terminal pleckstrin homology domain (2004), Biochem. Biophys. Res. Commun., 324, 1215-1219.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.138 expression of C-terminally FLAG-tagged and of EGFP-tagged wild-type and mutant enzymes in COS-1 cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.138 G2A site-directed mutagenesis, reduced activity compared to the wild-type enzyme Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.138 cytoplasmic vesicle
-
 Homo sapiens 31410
-
2.7.1.138 membrane bound to, probably via the pleckstrin homology domain of the enzyme Homo sapiens 16020
-
2.7.1.138 additional information the enzyme is involved in vesicular trafficking and subcellular translocation involving its pleckstrin homology domain, the enzyme co-localizes with its substrate, overview Homo sapiens
-
-
2.7.1.138 perinuclear space
-
 Homo sapiens
-
-
2.7.1.138 plasma membrane
-
 Homo sapiens 5886
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.138 Ca2+ at 3 mM CaCl2 Homo sapiens
2.7.1.138 NaCl at 50 mM Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.138 ATP + ceramide Homo sapiens
-
 ADP + ceramide 1-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.138 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.138 ATP + ceramide
-
 Homo sapiens ADP + ceramide 1-phosphate
-
 ?
2.7.1.138 ATP + ceramide the pleckstrin homology domain is essential for activity, binding of liposomes Homo sapiens ADP + ceramide 1-phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.138 More subdomain structure of the enzyme, possessing a pleckstrin homology domain, a DAGK-like catalytic domain, and a Ca2+/calmodulin binding domain Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.7.1.138 CERK
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.1.138 30
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.138 7.2
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.138 ATP
-
 Homo sapiens