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Literature summary extracted from

  • Roskoski, R.Jr.
    Src protein-tyrosine kinase structure and regulation (2004), Biochem. Biophys. Res. Commun., 324, 1155-1164.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.10.2 additional information activation loop structure of Src and of Csk, autophosphorylation sites Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.7.10.2
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.10.2 cytoplasm
-
 Homo sapiens 5737
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.10.2 Mg2+ as MgATP- Rous sarcoma virus
2.7.10.2 Mg2+ as MgATP2- Gallus gallus
2.7.10.2 Mg2+ as MgATP2-, binds to Asp404, physiological cation, can be substituted by Mn2+ Homo sapiens
2.7.10.2 Mn2+
-
 Gallus gallus
2.7.10.2 Mn2+
-
 Rous sarcoma virus
2.7.10.2 Mn2+ binds to Asp404, can substitute for Mg2+ Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.10.2 ATP + a [protein]-L-tyrosine Gallus gallus
-
 ADP + a [protein]-L-tyrosine phosphate
-
 ?
2.7.10.2 ATP + a [protein]-L-tyrosine Homo sapiens
-
 ADP + a [protein]-L-tyrosine phosphate
-
 ?
2.7.10.2 ATP + a [protein]-L-tyrosine Rous sarcoma virus
-
 ADP + a [protein]-L-tyrosine phosphate
-
 ?
2.7.10.2 additional information Gallus gallus Src and Src-family protein-tyrosine kinases are proto-oncogenes important in cell morphology, motility, proliferation, and survival, regulation by reversible phosphorylation, overview ?
-
 ?
2.7.10.2 additional information Homo sapiens Src and Src-family protein-tyrosine kinases are proto-oncogenes important in cell morphology, motility, proliferation, and survival, regulation by reversible phosphorylation, overview ?
-
 ?
2.7.10.2 additional information Rous sarcoma virus Src and Src-family protein-tyrosine kinases are proto-oncogenes important in cell morphology, motility, proliferation, and survival, regulation by reversible phosphorylation, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.2 Gallus gallus
-
-
-
2.7.10.2 Homo sapiens
-
-
-
2.7.10.2 Rous sarcoma virus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.10.2 phosphoprotein enzyme autophosphorylates at the activation loop for activation, inhibition by phosphorylation at the regulatory tyrosine residue, phosphorylation sites, detailed overview Gallus gallus
2.7.10.2 phosphoprotein enzyme autophosphorylates at the activation loop for activation, inhibition by phosphorylation at the regulatory tyrosine residue, phosphorylation sites, detailed overview Rous sarcoma virus
2.7.10.2 phosphoprotein enzyme autophosphorylates at Tyr416 the activation loop for activation, inhibition of Src by phosphorylation at the regulatory tyrosine Tyr527 residue by the C-terminal Src kinase Csk, phosphorylation sites, detailed overview Homo sapiens

Reaction

EC Number Reaction Comment Organism Reaction ID
2.7.10.2 ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate structure-function relation ship, active site structure, catalytic mechanism involving the catalytic base Asp386 and enzyme regulation, overview Homo sapiens
a
2.7.10.2 ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate structure-function relationship, active site structure, catalytic mechanism and enzyme regulation, overview Gallus gallus
a
2.7.10.2 ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate structure-function relationship, active site structure, catalytic mechanism and enzyme regulation, overview Rous sarcoma virus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.10.2 bladder Frk, Src, Fyn, Yes Homo sapiens
-
2.7.10.2 brain Frk, Src, Fyn, Yes Homo sapiens
-
2.7.10.2 breast Frk, Brk, Src, Fyn, Yes Homo sapiens
-
2.7.10.2 colon Brk, Frk, Src, Fyn, Yes Homo sapiens
-
2.7.10.2 hematopoietic cell Blk, Fgr, Hck, Lck, and Lyn, primarily, Src, Fyn, Yes Homo sapiens
-
2.7.10.2 keratinocyte Srm, Src, Fyn, Yes Homo sapiens
-
2.7.10.2 lymphoid cell Frk, Src, Fyn, Yes Homo sapiens
-
2.7.10.2 additional information Src is dormant during most of the cell cycle, Src, Fyn, Yes are expressed in all cell types Homo sapiens
-
2.7.10.2 prostate Brk, Src, Fyn, Yes Homo sapiens
-
2.7.10.2 small intestine Brk, Src, Fyn, Yes Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.10.2 ATP + a [protein]-L-tyrosine
-
 Gallus gallus ADP + a [protein]-L-tyrosine phosphate
-
 ?
2.7.10.2 ATP + a [protein]-L-tyrosine
-
 Homo sapiens ADP + a [protein]-L-tyrosine phosphate
-
 ?
2.7.10.2 ATP + a [protein]-L-tyrosine
-
 Rous sarcoma virus ADP + a [protein]-L-tyrosine phosphate
-
 ?
2.7.10.2 ATP + a [protein]-L-tyrosine substrate docking-site and binding structure of Src involving R279, R281, and R283 Homo sapiens ADP + a [protein]-L-tyrosine phosphate
-
 ?
2.7.10.2 additional information Src and Src-family protein-tyrosine kinases are proto-oncogenes important in cell morphology, motility, proliferation, and survival, regulation by reversible phosphorylation, overview Gallus gallus ?
-
 ?
2.7.10.2 additional information Src and Src-family protein-tyrosine kinases are proto-oncogenes important in cell morphology, motility, proliferation, and survival, regulation by reversible phosphorylation, overview Homo sapiens ?
-
 ?
2.7.10.2 additional information Src and Src-family protein-tyrosine kinases are proto-oncogenes important in cell morphology, motility, proliferation, and survival, regulation by reversible phosphorylation, overview Rous sarcoma virus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.10.2 More enzyme consists of an N-terminal myristoyl group, a unique segment, a SH2 and a SH3 domain, protein-tyrosine kinase domain, and a C-terminal regulatory domain, Src protein-tyrosine kinase structure and organization, overview Gallus gallus
2.7.10.2 More enzyme consists of an N-terminal myristoyl group, a unique segment, a SH2 and a SH3 domain, protein-tyrosine kinase domain, and a C-terminal regulatory domain, Src protein-tyrosine kinase structure and organization, overview Rous sarcoma virus
2.7.10.2 More enzyme consists of an N-terminal myristoyl group, a unique segment, a SH2 and a SH3 domain, protein-tyrosine kinase domain, and a C-terminal regulatory domain, Src protein-tyrosine kinase structure and organization, overview, active and inactive conformation of Src, structure of Csk Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.7.10.2 Blk
-
 Homo sapiens
2.7.10.2 Brk
-
 Homo sapiens
2.7.10.2 C-terminal Src kinase
-
 Homo sapiens
2.7.10.2 Csk
-
 Homo sapiens
2.7.10.2 Fgr
-
 Homo sapiens
2.7.10.2 FRK
-
 Homo sapiens
2.7.10.2 Fyn
-
 Homo sapiens
2.7.10.2 HCK
-
 Homo sapiens
2.7.10.2 Lck
-
 Homo sapiens
2.7.10.2 Lyn
-
 Homo sapiens
2.7.10.2 More the Src kinase family contains 11 members, i.e. protein tyrosine kinases Blk, Brk, Fgr, Frk, Fyn, Hck, Lck, Lyn, Src, Srm, and Yes Homo sapiens
2.7.10.2 PTK
-
 Homo sapiens
2.7.10.2 Src
-
 Gallus gallus
2.7.10.2 Src
-
 Homo sapiens
2.7.10.2 Src protein-tyrosine kinase
-
 Gallus gallus
2.7.10.2 Src protein-tyrosine kinase
-
 Homo sapiens
2.7.10.2 Src protein-tyrosine kinase
-
 Rous sarcoma virus
2.7.10.2 Srm
-
 Homo sapiens
2.7.10.2 v-Src
-
 Rous sarcoma virus
2.7.10.2 Yes
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.10.2 ATP as MgATP-, binding site structure Homo sapiens
2.7.10.2 ATP as MgATP2-, binding site structure Gallus gallus
2.7.10.2 ATP as MgATP2-, binding site structure Rous sarcoma virus