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Literature summary extracted from

  • Hascakova-Bartova, R.; Pouillon, V.; Dewaste, V.; Moreau, C.; Jacques, C.; Banting, G.; Schurmans, S.; Erneux, C.
    Identification and subcellular distribution of endogenous Ins(1,4,5)P(3) 3-kinase B in mouse tissues (2004), Biochem. Biophys. Res. Commun., 323, 920-925.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.127 expression of isozymes IP3-3KA, IP3-3KB, and IP3-3KC in COS-7 cells Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.127 particle-bound probably endoplasmic reticulum Mus musculus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.127 Ca2+ at 0.01 mM Mus musculus
2.7.1.127 Mg2+
-
Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.127 48000
-
x * 53000, recombinant isozyme IP3-3KA, SDS-PAGE, x * 98000, recombinant isozyme IP3-3KC, SDS-PAGE, x * 125000, recombinant isozyme IP3-3KB, SDS-PAGE, x * 48000, native brain isozyme IP3-3KA, SDS-PAGE, x * 110000-120000, native isozyme IP3-3KB, tissue-dependent, SDS-PAGE Mus musculus
2.7.1.127 53000
-
x * 53000, recombinant isozyme IP3-3KA, SDS-PAGE, x * 98000, recombinant isozyme IP3-3KC, SDS-PAGE, x * 125000, recombinant isozyme IP3-3KB, SDS-PAGE, x * 48000, native brain isozyme IP3-3KA, SDS-PAGE, x * 110000-120000, native isozyme IP3-3KB, tissue-dependent, SDS-PAGE Mus musculus
2.7.1.127 98000
-
x * 53000, recombinant isozyme IP3-3KA, SDS-PAGE, x * 98000, recombinant isozyme IP3-3KC, SDS-PAGE, x * 125000, recombinant isozyme IP3-3KB, SDS-PAGE, x * 48000, native brain isozyme IP3-3KA, SDS-PAGE, x * 110000-120000, native isozyme IP3-3KB, tissue-dependent, SDS-PAGE Mus musculus
2.7.1.127 125000
-
x * 53000, recombinant isozyme IP3-3KA, SDS-PAGE, x * 98000, recombinant isozyme IP3-3KC, SDS-PAGE, x * 125000, recombinant isozyme IP3-3KB, SDS-PAGE, x * 48000, native brain isozyme IP3-3KA, SDS-PAGE, x * 110000-120000, native isozyme IP3-3KB, tissue-dependent, SDS-PAGE Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.127 Mus musculus
-
wild-type strain C57BL/6 and enzyme-deficient strain, 3 isozymes IP3-3KA, IP3-3KB, and IP3-3KC
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.1.127 proteolytic modification isozyme IP3-3KB is sensitive to proteolysis at the N-terminus generating active fragments of lower molecular mass Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.127 brain higher expression of isozyme IP3-3KB Mus musculus
-
2.7.1.127 lung higher expression of isozyme IP3-3KB Mus musculus
-
2.7.1.127 additional information tissue-dependent expression of isozyme IP3-3KB Mus musculus
-
2.7.1.127 thymus higher expression of isozyme IP3-3KB Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.127 0.00044
-
mouse brain second particulate fraction Mus musculus
2.7.1.127 0.0026
-
recombinant enzyme in the first particulate fraction of transfected COS-7 cells Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
Mus musculus ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
?

Subunits

EC Number Subunits Comment Organism
2.7.1.127 ? x * 53000, recombinant isozyme IP3-3KA, SDS-PAGE, x * 98000, recombinant isozyme IP3-3KC, SDS-PAGE, x * 125000, recombinant isozyme IP3-3KB, SDS-PAGE, x * 48000, native brain isozyme IP3-3KA, SDS-PAGE, x * 110000-120000, native isozyme IP3-3KB, tissue-dependent, SDS-PAGE Mus musculus

Synonyms

EC Number Synonyms Comment Organism
2.7.1.127 inositol 1,4,5-trisphosphate 3-kinase
-
Mus musculus
2.7.1.127 Ins(1,4,5)P(3) 3-kinase B
-
Mus musculus
2.7.1.127 IP3-3K
-
Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.127 ATP
-
Mus musculus