EC Number | Cloned (Comment) | Organism |
---|---|---|
2.7.1.127 | expression of isozymes IP3-3KA, IP3-3KB, and IP3-3KC in COS-7 cells | Mus musculus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.7.1.127 | particle-bound | probably endoplasmic reticulum | Mus musculus | - |
- |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.127 | Ca2+ | at 0.01 mM | Mus musculus | |
2.7.1.127 | Mg2+ | - |
Mus musculus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.7.1.127 | 48000 | - |
x * 53000, recombinant isozyme IP3-3KA, SDS-PAGE, x * 98000, recombinant isozyme IP3-3KC, SDS-PAGE, x * 125000, recombinant isozyme IP3-3KB, SDS-PAGE, x * 48000, native brain isozyme IP3-3KA, SDS-PAGE, x * 110000-120000, native isozyme IP3-3KB, tissue-dependent, SDS-PAGE | Mus musculus |
2.7.1.127 | 53000 | - |
x * 53000, recombinant isozyme IP3-3KA, SDS-PAGE, x * 98000, recombinant isozyme IP3-3KC, SDS-PAGE, x * 125000, recombinant isozyme IP3-3KB, SDS-PAGE, x * 48000, native brain isozyme IP3-3KA, SDS-PAGE, x * 110000-120000, native isozyme IP3-3KB, tissue-dependent, SDS-PAGE | Mus musculus |
2.7.1.127 | 98000 | - |
x * 53000, recombinant isozyme IP3-3KA, SDS-PAGE, x * 98000, recombinant isozyme IP3-3KC, SDS-PAGE, x * 125000, recombinant isozyme IP3-3KB, SDS-PAGE, x * 48000, native brain isozyme IP3-3KA, SDS-PAGE, x * 110000-120000, native isozyme IP3-3KB, tissue-dependent, SDS-PAGE | Mus musculus |
2.7.1.127 | 125000 | - |
x * 53000, recombinant isozyme IP3-3KA, SDS-PAGE, x * 98000, recombinant isozyme IP3-3KC, SDS-PAGE, x * 125000, recombinant isozyme IP3-3KB, SDS-PAGE, x * 48000, native brain isozyme IP3-3KA, SDS-PAGE, x * 110000-120000, native isozyme IP3-3KB, tissue-dependent, SDS-PAGE | Mus musculus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.127 | Mus musculus | - |
wild-type strain C57BL/6 and enzyme-deficient strain, 3 isozymes IP3-3KA, IP3-3KB, and IP3-3KC | - |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
2.7.1.127 | proteolytic modification | isozyme IP3-3KB is sensitive to proteolysis at the N-terminus generating active fragments of lower molecular mass | Mus musculus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.1.127 | brain | higher expression of isozyme IP3-3KB | Mus musculus | - |
2.7.1.127 | lung | higher expression of isozyme IP3-3KB | Mus musculus | - |
2.7.1.127 | additional information | tissue-dependent expression of isozyme IP3-3KB | Mus musculus | - |
2.7.1.127 | thymus | higher expression of isozyme IP3-3KB | Mus musculus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.7.1.127 | 0.00044 | - |
mouse brain second particulate fraction | Mus musculus |
2.7.1.127 | 0.0026 | - |
recombinant enzyme in the first particulate fraction of transfected COS-7 cells | Mus musculus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.127 | ATP + 1D-myo-inositol 1,4,5-trisphosphate | - |
Mus musculus | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.7.1.127 | ? | x * 53000, recombinant isozyme IP3-3KA, SDS-PAGE, x * 98000, recombinant isozyme IP3-3KC, SDS-PAGE, x * 125000, recombinant isozyme IP3-3KB, SDS-PAGE, x * 48000, native brain isozyme IP3-3KA, SDS-PAGE, x * 110000-120000, native isozyme IP3-3KB, tissue-dependent, SDS-PAGE | Mus musculus |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.1.127 | inositol 1,4,5-trisphosphate 3-kinase | - |
Mus musculus |
2.7.1.127 | Ins(1,4,5)P(3) 3-kinase B | - |
Mus musculus |
2.7.1.127 | IP3-3K | - |
Mus musculus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.127 | ATP | - |
Mus musculus |