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Literature summary extracted from

  • Arioka, M.; Nakashima, S.; Shibasaki, Y.; Kitamoto, K.
    Dibasic amino acid residues at the carboxy-terminal end of kinase homology domain participate in the plasma membrane localization and function of phosphatidylinositol 5-kinase gamma (2004), Biochem. Biophys. Res. Commun., 319, 456-463.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.68 phosphatidic acid activation Mus musculus
2.7.1.68 small GTPase ARF/phosphatidic acid regulation of isozyme gamma Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.68 functional complementation of a yeast Mss4-1 mutant strain YOC808 by the wild-type isozyme gamma and the deletion mutants localizing to the plasma membrane, while the deletion mutants localized to the cytosol cannot support yeast cell growth, expression of wild-type and mutant type I HA-tagged or EGFP-tagged isozymes gamma in Neuro 2A cells and in COS-1 cells Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.68 additional information construction of N-terminal deletion mutants DELTA68, DELTA 72, and DELTA74 are still localized to the plasma membrane, while the N-terminal deletion mutants DELTA82, DELTA 97 are mislocated to the cytosol, construction of C-terminal deletion mutant DELTA446 is still localized to the plasma membrane, while the N-terminal deletion mutant DELTA444 is mislocated to the cytosol, mutant fusion protein DELTA68-DELTA444 localizes to the plasma membrane Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.68 plasma membrane type I isozyme gamma, the highly conserved central kinase domain KHD is necessary and sufficient for plasma membrane localization, with the C-termnal Arg-Lys dibasic sequence being responsible for plasma membrane targeting Mus musculus 5886
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.68 Mg2+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.68 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate Mus musculus 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.68 Mus musculus
-
 type I enzymes, isozyme gamma
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.68 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 Mus musculus ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?
2.7.1.68 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking Mus musculus ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.68 phosphatidylinositol 5-kinase gamma
-
 Mus musculus
2.7.1.68 PIP5Kgamma
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.68 ATP
-
 Mus musculus