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Literature summary extracted from

  • Roskoski, R.Jr.
    The ErbB/HER receptor protein-tyrosine kinases and cancer (2004), Biochem. Biophys. Res. Commun., 319, 1-11.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.10.1 pharmacology ErbB family receptor kinases are targets for anticancer drugs, e.g. gefitinib or erlotinib in the treatment of non-small lung cancer or colorectal cancer, treatment with therapeutic antibodies in case of breast cancer Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.10.1 genes encoding ErbB receptor protein-tyrosine kinase 1-4 are located on different chromosomes Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.10.1 additional information null mutations of any of the ErbB family enzymes result in embryonic lethality Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.10.1 OSI-774 i.e. erlotinib, inhibits EGF receptor protein tyrosine kinase, binding to EGF receptor kinase, structure overview, anticancer drug Homo sapiens
2.7.10.1 ZD1839 i.e. gefitinib, reversible inhibition of ErbB1, competitive to ATP, binding to EGF receptor kinase, structure overview, anticancer drug Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.10.1 membrane transmembrane protein Homo sapiens 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.10.1 Mg2+ MgATP- Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.10.1 ATP + a [protein]-L-tyrosine Homo sapiens regulation mechanisms and ligand binding, ligand binding induces a conformational change, overview ADP + a [protein]-L-tyrosine phosphate
-
 ?
2.7.10.1 additional information Homo sapiens ErbB family enzymes are absolutely required for viability of embryos ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.1 Homo sapiens
-
 several isozymes of both ErbB receptor protein-tyrosine kinase and HER receptor protein-tyrosine kinase
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.10.1 glycoprotein ErbB family proteins are N-glycosylated to about 20% of their mass, deglycosylation causes loss of 70% protein tyrosine kinase activity Homo sapiens
2.7.10.1 phosphoprotein phosphorylation at tyrosine residues, autophosphorylation of the ErbB receptor dimer Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.10.1 bladder high expression level of ErbB1 receptor Homo sapiens
-
2.7.10.1 breast high expression level of ErbB1 receptor Homo sapiens
-
2.7.10.1 kidney high expression level of ErbB1 receptor Homo sapiens
-
2.7.10.1 non-small cell lung cancer cell high expression level of ErbB1 receptor Homo sapiens
-
2.7.10.1 prostate cancer cell high expression level of ErbB1 receptor Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.10.1 ATP + a [protein]-L-tyrosine
-
 Homo sapiens ADP + a [protein]-L-tyrosine phosphate
-
 ?
2.7.10.1 ATP + a [protein]-L-tyrosine regulation mechanisms and ligand binding, ligand binding induces a conformational change, overview Homo sapiens ADP + a [protein]-L-tyrosine phosphate
-
 ?
2.7.10.1 additional information ErbB family enzymes are absolutely required for viability of embryos Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.10.1 dimer dimerization of ErbB receptor results in activation, trans-autophosphorylation, and initiation of signaling occurs Homo sapiens
2.7.10.1 More the ErbB family enzymes possess a single transmembrane segment, a growth-factor-binding ectodomain, an intracellular protein-tyrosine kinase catalytic domain, and a tyrosine-containing cytoplasmic tail, domain structure overview, enzyme activation involves major rotation of the ectodomain Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.7.10.1 EGF receptor protein-tyrosine kinase
-
 Homo sapiens
2.7.10.1 Egfr
-
 Homo sapiens
2.7.10.1 epidermal growth factor receptor
-
 Homo sapiens
2.7.10.1 ErbB receptor protein-tyrosine kinase
-
 Homo sapiens
2.7.10.1 HER receptor protein-tyrosine kinase
-
 Homo sapiens
2.7.10.1 More WebB and HER receptor protein-tyrosine kinase, as well as epidermal growth factor receptor belong to the ErbB family, overview Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.10.1 ATP MgATP- Homo sapiens