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Literature summary extracted from

  • Keszler, G.; Virga, S.; Spasokoukotskaja, T.; Bauer, P.I.; Sasvari-Szekely, M.; Staub, M.
    Activation of deoxycytidine kinase by deoxyadenosine: implications in deoxyadenosine-mediated cytotoxicity (2005), Arch. Biochem. Biophys., 436, 69-77.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.74 2'-deoxyadenosine/deoxycoformycin no stimulation of enzyme activity by either compound if applied alone, with both compound at 0.01 mM 2.4fold activation occurs Homo sapiens
2.7.1.74 2-chloro-2'-deoxyadenosine 2.4fold activation at 0.003 mM, activation is slightly inhibited by 3-aminobenzamide, the activation of the enzyme is a first step in 2-chloro-2'-deoxyadenosine-induced cytotoxicity Homo sapiens
2.7.1.74 aphidicolin
-
 Homo sapiens
2.7.1.74 etoposide
-
 Homo sapiens
2.7.1.74 additional information enzyme is activated by inhibitors of signal transduction enzymes, overview, deoxycytidine prevents activation of the enzyme, no activation by PD 98059 and SB 203580 in presence of deoxycytidine Homo sapiens
2.7.1.74 PD 153035 i.e. 4-(3-bromoanilino)-6,7-dimethoxy-quinazinoline Homo sapiens
2.7.1.74 PD 98059 i.e. 2'-amino-3'-methoxyflavone, in absence of deoxycytidine Homo sapiens
2.7.1.74 SB 203580 in absence of deoxycytidine Homo sapiens
2.7.1.74 tyrphostin A47
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.74 sorbitol
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.74 Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.74 ATP + 2'-deoxycytidine Homo sapiens
-
 ADP + 2'-deoxycytidine 5'-phosphate
-
 ?
2.7.1.74 additional information Homo sapiens the activation of the enzyme is a first step in 2-chloro-2'-deoxyadenosine-induced cytotoxicity ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.74 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.74 lymphocyte tonsillar Homo sapiens
-
2.7.1.74 tonsil lymphocyte Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.74 additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.74 ATP + 2'-deoxycytidine
-
 Homo sapiens ADP + 2'-deoxycytidine 5'-phosphate
-
 ?
2.7.1.74 ATP + 2-chloro-2'-deoxyadenosine i.e. cladribine Homo sapiens ADP + 2-chloro-2'-deoxyadenosine 5'-phosphate
-
 ?
2.7.1.74 additional information the activation of the enzyme is a first step in 2-chloro-2'-deoxyadenosine-induced cytotoxicity Homo sapiens ?
-
 ?
2.7.1.74 additional information the enzyme shows broad substrate specificity Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.74 dCK
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.74 7.6
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.74 ATP
-
 Homo sapiens