Literature summary extracted from

Aslan, M.; Ozben, T.
Oxidants in receptor tyrosine kinase signal transduction pathways (2003), Antioxid. Redox Signal., 5, 781-788.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
2.7.10.1	angiotensin II	induces transactivation of epidermal growth factor receptor, mechanism	Homo sapiens
2.7.10.1	additional information	reactive oxygen species, such as O2.- and H2O2, function as mitogenic mediators of activated growth-factor-receptor signaling	Homo sapiens

EC Number	Inhibitors	Comment	Organism	Structure
2.7.10.1	ebselen	-	Bos taurus

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
2.7.10.1	membrane	transmembrane proteins with a single transmembrane pass, a cytoplasmic domain, and an extracellular domain, overview	Homo sapiens	16020	-

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.7.10.1	additional information	Homo sapiens	activation of PDGF receptor growth factor results in increased intracellular Ca2+ flux and cytoplasmic pH changes, enzyme stimulates generation of reactive oxygen species, such as O2.- and H2O2, which function as mitogenic mediators of activated growth-factor-receptor signaling, overview, the EGFR signaling pathway functions in many cellular processes, including proliferation, cell migration, and apoptosis, signaling pathways, overview	?	-	?
2.7.10.1	additional information	Bos taurus	activation of PDGF receptor growth factor results in increased intracellular Ca2+ flux and cytoplasmic pH changes, enzyme stimulates generation of reactive oxygen species, which function as mitogenic mediators of activated growth-factor-receptor signaling, overview, the EGFR signaling pathway functions in many cellular processes, including proliferation, cell migration, and apoptosis, signaling pathways, overview	?	-	?

EC Number	Organism	UniProt	Comment	Textmining
2.7.10.1	Bos taurus	-	-	-
2.7.10.1	Homo sapiens	-	2 isozymes PDGF-alpha receptor and PDGF-beta receptor, 4 isozymes FGFR-1, FGFR-2, FGFR-3, and FGFR-4	-

EC Number	Posttranslational Modification	Comment	Organism
2.7.10.1	glycoprotein	epidermal growth factor receptor contains a glycosylated extracellular domain	Homo sapiens
2.7.10.1	phosphoprotein	7 autophosphorylation sites, specific binding sites for Src family protein kinases, in PDGF-beta receptor, epidermal growth factor receptor is autophosphorylated after ligand binding forming dimers or oligomers with itself or other members of the Erb family	Homo sapiens

EC Number	Source Tissue	Comment	Organism	Textmining
2.7.10.1	A-431 cell	epidermoid carcinoma	Homo sapiens	-
2.7.10.1	aorta	smooth muscle	Homo sapiens	-
2.7.10.1	chondrocyte	fibroblast growth factor receptor	Homo sapiens	-
2.7.10.1	endothelial cell	-	Homo sapiens	-
2.7.10.1	fibroblast	lung	Homo sapiens	-
2.7.10.1	heart	vascular endothelial growth factor receptor	Homo sapiens	-
2.7.10.1	Hep-G2 cell	-	Homo sapiens	-
2.7.10.1	lung	fibroblast	Homo sapiens	-
2.7.10.1	macrophage	-	Homo sapiens	-
2.7.10.1	myocyte	tracheal	Bos taurus	-
2.7.10.1	neutrophil	-	Homo sapiens	-
2.7.10.1	placenta	-	Homo sapiens	-
2.7.10.1	smooth muscle	aortic	Homo sapiens	-
2.7.10.1	trachea	-	Bos taurus	-

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.7.10.1	additional information	activation of PDGF receptor growth factor results in increased intracellular Ca2+ flux and cytoplasmic pH changes, enzyme stimulates generation of reactive oxygen species, such as O2.- and H2O2, which function as mitogenic mediators of activated growth-factor-receptor signaling, overview, the EGFR signaling pathway functions in many cellular processes, including proliferation, cell migration, and apoptosis, signaling pathways, overview	Homo sapiens	?	-	?
2.7.10.1	additional information	activation of PDGF receptor growth factor results in increased intracellular Ca2+ flux and cytoplasmic pH changes, enzyme stimulates generation of reactive oxygen species, which function as mitogenic mediators of activated growth-factor-receptor signaling, overview, the EGFR signaling pathway functions in many cellular processes, including proliferation, cell migration, and apoptosis, signaling pathways, overview	Bos taurus	?	-	?

EC Number	Subunits	Comment	Organism
2.7.10.1	dimer	platelet-derived growth factor receptor is a homo- or heterodimer wih A and B chains being assembled in different combinations, i.e. PDGF-alpha receptor or PDGF-beta receptor	Homo sapiens
2.7.10.1	monomer	epidermal growth factor receptor	Homo sapiens
2.7.10.1	oligomer	epidermal growth factor receptor is autophosphorylated after ligand binding forming dimers or oligomers with itself or other members of the Erb family	Homo sapiens

EC Number	Synonyms	Comment	Organism
2.7.10.1	Egfr	-	Homo sapiens
2.7.10.1	ephrine receptor	-	Homo sapiens
2.7.10.1	epidermal growth factor receptor	-	Homo sapiens
2.7.10.1	FGFR	-	Homo sapiens
2.7.10.1	fibroblast growth factor receptor	-	Homo sapiens
2.7.10.1	hepatocyte growth factor receptor	-	Homo sapiens
2.7.10.1	insulin receptor	-	Homo sapiens
2.7.10.1	insulin-like growth factor receptor	-	Homo sapiens
2.7.10.1	macrophage colony-stimulating factor receptor	-	Homo sapiens
2.7.10.1	More	epidermal growth factor receptor is a member of the Erb family	Homo sapiens
2.7.10.1	nerve growth factor receptor	-	Homo sapiens
2.7.10.1	PDGF-alpha receptor	-	Homo sapiens
2.7.10.1	PDGF-beta receptor	-	Homo sapiens
2.7.10.1	PDGFR	-	Homo sapiens
2.7.10.1	PDGFR	-	Bos taurus
2.7.10.1	platelet-derived growth factor receptor	-	Homo sapiens
2.7.10.1	platelet-derived growth factor receptor	-	Bos taurus
2.7.10.1	receptor tyrosine kinase	-	Homo sapiens
2.7.10.1	RPTK	-	Homo sapiens
2.7.10.1	vascular endothelial growth factor receptor	-	Homo sapiens
2.7.10.1	VEGFR	-	Homo sapiens