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  • Flamm, R.K.; Vojtko, C.; Chu, D.T.; Li, Q.; Beyer, J.; Hensey, D.; Ramer, N.; Clement, J.J.; Tanaka, S.K.
    In vitro evaluation of ABT-719, a novel DNA gyrase inhibitor (1995), Antimicrob. Agents Chemother., 39, 964-970.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.6.2.2 ABT-719 i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00003 mg/ml Acinetobacter calcoaceticus
5.6.2.2 ABT-719 i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00025 mg/ml Bacteroides fragilis
5.6.2.2 ABT-719 i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00025 mg/ml Bacteroides thetaiotaomicron
5.6.2.2 ABT-719 i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00006 mg/ml Citrobacter freundii
5.6.2.2 ABT-719 i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00003 mg/ml Citrobacter spp.
5.6.2.2 ABT-719 i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00012 mg/ml Clostridioides difficile
5.6.2.2 ABT-719 i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00025 mg/ml Clostridium perfringens
5.6.2.2 ABT-719 i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00012 mg/ml Corynebacterium sp.
5.6.2.2 ABT-719 i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00012 mg/ml Enterococcus faecium
5.6.2.2 ABT-719 i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00025 mg/ml Enterococcus sp.
5.6.2.2 ABT-719 i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.000008 mg/ml Escherichia coli
5.6.2.2 ABT-719 i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.000003 mg/ml Haemophilus influenzae
5.6.2.2 ABT-719 i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00003 mg/ml Klebsiella sp.
5.6.2.2 ABT-719 i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00025 mg/ml Legionella sp.
5.6.2.2 ABT-719 i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00003 mg/ml Listeria monocytogenes
5.6.2.2 ABT-719 i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.000015 mg/ml Moraxella catarrhalis
5.6.2.2 ABT-719 i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00003 mg/ml Morganella morganii
5.6.2.2 ABT-719 i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.016 mg/ml Mycobacterium avium
5.6.2.2 ABT-719 i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.000015 mg/ml Neisseria gonorrhoeae
5.6.2.2 ABT-719 i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00025 mg/ml Peptostreptococcus sp.
5.6.2.2 ABT-719 i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00025 mg/ml Prevotella bivia
5.6.2.2 ABT-719 i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00003 mg/ml Proteus mirabilis
5.6.2.2 ABT-719 i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00003 mg/ml Providencia rettgeri
5.6.2.2 ABT-719 i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00003 mg/ml Providencia stuartii
5.6.2.2 ABT-719 i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00012 mg/ml Pseudomonas aeruginosa
5.6.2.2 ABT-719 i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.000015 mg/ml Salmonella sp.
5.6.2.2 ABT-719 i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00006 mg/ml Serratia marcescens
5.6.2.2 ABT-719 i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative Shigella sp.
5.6.2.2 ABT-719 i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.000015 mg/ml for strain CiproS, 0.00025 mg/ml for strain CiproR, and 0.001 mg/ml for the methicillin-resistant strain Staphylococcus aureus
5.6.2.2 ABT-719 i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00003 mg/ml for the wild-type and 0.00025 mg/ml for the methicillin-resistant strain Staphylococcus epidermidis
5.6.2.2 ABT-719 i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00006 mg/ml Streptococcus agalactiae
5.6.2.2 ABT-719 i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00003 mg/ml for the wild-type strain and for the strain Pen I/R Streptococcus pneumoniae
5.6.2.2 ABT-719 i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00003 mg/ml Streptococcus pyogenes
5.6.2.2 ABT-719 i.e. A-86719.1 or 8-(3-(S)-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4H-4-oxo-quinolizine-3-carboxylic acid hydrochloride monohydrate, in vitro evaluation, 2-pyrisone derivative, MIC90 is 0.00003 mg/ml Streptococcus viridans
5.6.2.2 Ciprofloxacin MIC90 is 0.0005 mg/ml Acinetobacter calcoaceticus
5.6.2.2 Ciprofloxacin MIC90 is 0.016 mg/ml Bacteroides fragilis
5.6.2.2 Ciprofloxacin MIC90 is 0.032 mg/ml Bacteroides thetaiotaomicron
5.6.2.2 Ciprofloxacin MIC90 is 0.00012 mg/ml Citrobacter freundii
5.6.2.2 Ciprofloxacin MIC90 is 0.00003 mg/ml Citrobacter spp.
5.6.2.2 Ciprofloxacin MIC90 is 0.016 mg/ml Clostridioides difficile
5.6.2.2 Ciprofloxacin MIC90 is 0.0005 mg/ml Clostridium perfringens
5.6.2.2 Ciprofloxacin MIC90 is 0.002 mg/ml Corynebacterium sp.
5.6.2.2 Ciprofloxacin MIC90 is 0.002 mg/ml Enterococcus faecium
5.6.2.2 Ciprofloxacin MIC90 is 0.064 mg/ml Enterococcus sp.
5.6.2.2 Ciprofloxacin MIC90 is 0.000015 mg/ml Escherichia coli
5.6.2.2 Ciprofloxacin MIC90 is 0.00003 mg/ml Haemophilus influenzae
5.6.2.2 Ciprofloxacin MIC90 is 0.00006 mg/ml Klebsiella sp.
5.6.2.2 Ciprofloxacin MIC90 is 0.00025 mg/ml Legionella sp.
5.6.2.2 Ciprofloxacin MIC90 is 0.002 mg/ml Listeria monocytogenes
5.6.2.2 Ciprofloxacin MIC90 is 0.00003 mg/ml Moraxella catarrhalis
5.6.2.2 Ciprofloxacin MIC90 is 0.00003 mg/ml Morganella morganii
5.6.2.2 Ciprofloxacin MIC90 is 0.016 mg/ml Mycobacterium avium
5.6.2.2 Ciprofloxacin MIC90 is 0.00006 mg/ml Neisseria gonorrhoeae
5.6.2.2 Ciprofloxacin MIC90 is 0.004 mg/ml Peptostreptococcus sp.
5.6.2.2 Ciprofloxacin MIC90 is 0.016 mg/ml Prevotella bivia
5.6.2.2 Ciprofloxacin MIC90 is 0.00006 mg/ml Proteus mirabilis
5.6.2.2 Ciprofloxacin MIC90 is 0.00006 mg/ml Providencia rettgeri
5.6.2.2 Ciprofloxacin MIC90 is 0.00012 mg/ml Providencia stuartii
5.6.2.2 Ciprofloxacin MIC90 is 0.0005 mg/ml Pseudomonas aeruginosa
5.6.2.2 Ciprofloxacin MIC90 is 0.00006 mg/ml Salmonella sp.
5.6.2.2 Ciprofloxacin MIC90 is 0.00025 mg/ml Serratia marcescens
5.6.2.2 Ciprofloxacin
-
 Shigella sp.
5.6.2.2 Ciprofloxacin MIC90 is 0.0005 mg/ml for strain CiproS, 0.064 mg/ml for strain CiproR, and 0.128 mg/ml for the methicillin-resistant strain Staphylococcus aureus
5.6.2.2 Ciprofloxacin MIC90 is 0.00025 mg/ml for the wild-type and 0.032 mg/ml for the methicillin-resistant strain Staphylococcus epidermidis
5.6.2.2 Ciprofloxacin MIC90 is 0.002 mg/ml Streptococcus agalactiae
5.6.2.2 Ciprofloxacin MIC90 is 0.002 mg/ml for the wild-type strain and for the strain Pen I/R Streptococcus pneumoniae
5.6.2.2 Ciprofloxacin MIC90 is 0.002 mg/ml Streptococcus pyogenes
5.6.2.2 Ciprofloxacin MIC90 is 0.002 mg/ml Streptococcus viridans
5.6.2.2 clinafloxacin MIC90 is 0.00006 mg/ml Acinetobacter calcoaceticus
5.6.2.2 clinafloxacin MIC90 is 0.00025 mg/ml Bacteroides fragilis
5.6.2.2 clinafloxacin MIC90 is 0.0005 mg/ml Bacteroides thetaiotaomicron
5.6.2.2 clinafloxacin MIC90 is 0.00012 mg/ml Citrobacter freundii
5.6.2.2 clinafloxacin MIC90 is 0.00003 mg/ml Citrobacter spp.
5.6.2.2 clinafloxacin MIC90 is 0.00025 mg/ml Clostridioides difficile
5.6.2.2 clinafloxacin MIC90 is 0.00025 mg/ml Clostridium perfringens
5.6.2.2 clinafloxacin MIC90 is 0.00012 mg/ml Corynebacterium sp.
5.6.2.2 clinafloxacin MIC90 is 0.00025 mg/ml Enterococcus faecium
5.6.2.2 clinafloxacin MIC90 is 0.002 mg/ml Enterococcus sp.
5.6.2.2 clinafloxacin MIC90 is 0.000015 mg/ml Escherichia coli
5.6.2.2 clinafloxacin MIC90 is 0.000003 mg/ml Haemophilus influenzae
5.6.2.2 clinafloxacin MIC90 is 0.00003 mg/ml Klebsiella sp.
5.6.2.2 clinafloxacin MIC90 is 0.00012 mg/ml Legionella sp.
5.6.2.2 clinafloxacin MIC90 is 0.00012 mg/ml Listeria monocytogenes
5.6.2.2 clinafloxacin MIC90 is 0.000015 mg/ml Moraxella catarrhalis
5.6.2.2 clinafloxacin MIC90 is 0.00003 mg/ml Morganella morganii
5.6.2.2 clinafloxacin MIC90 is 0.064 mg/ml Mycobacterium avium
5.6.2.2 clinafloxacin MIC90 is 0.000015 mg/ml Neisseria gonorrhoeae
5.6.2.2 clinafloxacin MIC90 is 0.00025 mg/ml Peptostreptococcus sp.
5.6.2.2 clinafloxacin MIC90 is 0.00025 mg/ml Prevotella bivia
5.6.2.2 clinafloxacin MIC90 is 0.00003 mg/ml Proteus mirabilis
5.6.2.2 clinafloxacin MIC90 is 0.00003 mg/ml Providencia rettgeri
5.6.2.2 clinafloxacin MIC90 is 0.00003 mg/ml Providencia stuartii
5.6.2.2 clinafloxacin MIC90 is 0.00025 mg/ml Pseudomonas aeruginosa
5.6.2.2 clinafloxacin MIC90 is 0.00003 mg/ml Salmonella sp.
5.6.2.2 clinafloxacin MIC90 is 0.00006 mg/ml Serratia marcescens
5.6.2.2 clinafloxacin
-
 Shigella sp.
5.6.2.2 clinafloxacin MIC90 is 0.00003 mg/ml for strain CiproS, 0.001 mg/ml for strain CiproR, and 0.001 mg/ml for the methicillin-resistant strain Staphylococcus aureus
5.6.2.2 clinafloxacin MIC90 is 0.00003 mg/ml for the wild-type and 0.001 mg/ml for the methicillin-resistant strain Staphylococcus epidermidis
5.6.2.2 clinafloxacin MIC90 is 0.00025 mg/ml Streptococcus agalactiae
5.6.2.2 clinafloxacin MIC90 is 0.00012 mg/ml for the wild-type strain and 0.00025 mg/ml for the strain Pen I/R Streptococcus pneumoniae
5.6.2.2 clinafloxacin MIC90 is 0.00006 mg/ml Streptococcus pyogenes
5.6.2.2 clinafloxacin MIC90 is 0.00006 mg/ml Streptococcus viridans
5.6.2.2 additional information ciprofloxacin-resistant strain shows increased MIC90 values for the inhibitors compared to the wild-type strains Pseudomonas aeruginosa
5.6.2.2 sparfloxacin MIC90 is 0.00006 mg/ml Acinetobacter calcoaceticus
5.6.2.2 sparfloxacin MIC90 is 0.002 mg/ml Bacteroides fragilis
5.6.2.2 sparfloxacin MIC90 is 0.004 mg/ml Bacteroides thetaiotaomicron
5.6.2.2 sparfloxacin MIC90 is 0.00025 mg/ml Citrobacter freundii
5.6.2.2 sparfloxacin MIC90 is 0.00003 mg/ml Citrobacter spp.
5.6.2.2 sparfloxacin MIC90 is 0.004 mg/ml Clostridioides difficile
5.6.2.2 sparfloxacin MIC90 is 0.0005 mg/ml Clostridium perfringens
5.6.2.2 sparfloxacin MIC90 is 0.00025 mg/ml Corynebacterium sp.
5.6.2.2 sparfloxacin MIC90 is 0.0005 mg/ml Enterococcus faecium
5.6.2.2 sparfloxacin MIC90 is 0.001 mg/ml Enterococcus sp.
5.6.2.2 sparfloxacin MIC90 is 0.00003 mg/ml Escherichia coli
5.6.2.2 sparfloxacin MIC90 is 0.00003 mg/ml Haemophilus influenzae
5.6.2.2 sparfloxacin MIC90 is 0.00012 mg/ml Klebsiella sp.
5.6.2.2 sparfloxacin MIC90 is 0.00025 mg/ml Legionella sp.
5.6.2.2 sparfloxacin MIC90 is 0.00025 mg/ml Listeria monocytogenes
5.6.2.2 sparfloxacin MIC90 is 0.000015 mg/ml Moraxella catarrhalis
5.6.2.2 sparfloxacin MIC90 is 0.00025 mg/ml Morganella morganii
5.6.2.2 sparfloxacin MIC90 is 0.002 mg/ml Mycobacterium avium
5.6.2.2 sparfloxacin MIC90 is 0.000015 mg/ml Neisseria gonorrhoeae
5.6.2.2 sparfloxacin MIC90 is 0.0005 mg/ml Peptostreptococcus sp.
5.6.2.2 sparfloxacin MIC90 is 0.004 mg/ml Prevotella bivia
5.6.2.2 sparfloxacin MIC90 is 0.00025 mg/ml Proteus mirabilis
5.6.2.2 sparfloxacin MIC90 is 0.001 mg/ml Providencia rettgeri
5.6.2.2 sparfloxacin MIC90 is 0.0005 mg/ml Providencia stuartii
5.6.2.2 sparfloxacin MIC90 is 0.001 mg/ml Pseudomonas aeruginosa
5.6.2.2 sparfloxacin MIC90 is 0.00006 mg/ml Salmonella sp.
5.6.2.2 sparfloxacin MIC90 is 0.001 mg/ml Serratia marcescens
5.6.2.2 sparfloxacin
-
 Shigella sp.
5.6.2.2 sparfloxacin MIC90 is 0.00006 mg/ml for strain CiproS, 0.016 mg/ml for strain CiproR, and 0.008 mg/ml for the methicillin-resistant strain Staphylococcus aureus
5.6.2.2 sparfloxacin MIC90 is 0.00012 mg/ml for the wild-type and 0.008 mg/ml for the methicillin-resistant strain Staphylococcus epidermidis
5.6.2.2 sparfloxacin MIC90 is 0.001 mg/ml Streptococcus agalactiae
5.6.2.2 sparfloxacin MIC90 is 0.0005 mg/ml for the wild-type strain and 0.00025 mg/ml for the strain Pen I/R Streptococcus pneumoniae
5.6.2.2 sparfloxacin MIC90 is 0.0005 mg/ml Streptococcus pyogenes
5.6.2.2 sparfloxacin MIC90 is 0.00025 mg/ml Streptococcus viridans

Organism

EC Number Organism UniProt Comment Textmining
5.6.2.2 Acinetobacter calcoaceticus
-
-
-
5.6.2.2 Bacteroides fragilis
-
-
-
5.6.2.2 Bacteroides thetaiotaomicron
-
-
-
5.6.2.2 Citrobacter freundii
-
-
-
5.6.2.2 Citrobacter spp.
-
-
-
5.6.2.2 Clostridioides difficile
-
-
-
5.6.2.2 Clostridium perfringens
-
-
-
5.6.2.2 Corynebacterium sp.
-
-
-
5.6.2.2 Enterococcus faecium
-
-
-
5.6.2.2 Enterococcus sp.
-
-
-
5.6.2.2 Escherichia coli
-
-
-
5.6.2.2 Haemophilus influenzae
-
-
-
5.6.2.2 Klebsiella sp.
-
-
-
5.6.2.2 Legionella sp.
-
-
-
5.6.2.2 Listeria monocytogenes
-
-
-
5.6.2.2 Moraxella catarrhalis
-
-
-
5.6.2.2 Morganella morganii
-
-
-
5.6.2.2 Mycobacterium avium
-
-
-
5.6.2.2 Neisseria gonorrhoeae
-
-
-
5.6.2.2 Peptostreptococcus sp.
-
-
-
5.6.2.2 Prevotella bivia
-
-
-
5.6.2.2 Proteus mirabilis
-
-
-
5.6.2.2 Providencia rettgeri
-
-
-
5.6.2.2 Providencia stuartii
-
-
-
5.6.2.2 Pseudomonas aeruginosa
-
 strains AC1679-1682
-
5.6.2.2 Pseudomonas aeruginosa AC1679-1682
-
 strains AC1679-1682
-
5.6.2.2 Salmonella sp.
-
-
-
5.6.2.2 Serratia marcescens
-
-
-
5.6.2.2 Shigella sp.
-
-
-
5.6.2.2 Staphylococcus aureus
-
 strains CiproS and CiproR, and a methicillin-resistant strain
-
5.6.2.2 Staphylococcus aureus CiproS
-
 strains CiproS and CiproR, and a methicillin-resistant strain
-
5.6.2.2 Staphylococcus epidermidis
-
 wild-type and a methicillin-resistant strain
-
5.6.2.2 Streptococcus agalactiae
-
-
-
5.6.2.2 Streptococcus pneumoniae
-
 wild-type strain and strain Pen I/R
-
5.6.2.2 Streptococcus pyogenes
-
-
-
5.6.2.2 Streptococcus viridans
-
-
-

Synonyms

EC Number Synonyms Comment Organism
5.6.2.2 DNA gyrase
-
 Staphylococcus aureus
5.6.2.2 DNA gyrase
-
 Haemophilus influenzae
5.6.2.2 DNA gyrase
-
 Escherichia coli
5.6.2.2 DNA gyrase
-
 Pseudomonas aeruginosa
5.6.2.2 DNA gyrase
-
 Acinetobacter calcoaceticus
5.6.2.2 DNA gyrase
-
 Serratia marcescens
5.6.2.2 DNA gyrase
-
 Corynebacterium sp.
5.6.2.2 DNA gyrase
-
 Neisseria gonorrhoeae
5.6.2.2 DNA gyrase
-
 Mycobacterium avium
5.6.2.2 DNA gyrase
-
 Streptococcus pneumoniae
5.6.2.2 DNA gyrase
-
 Proteus mirabilis
5.6.2.2 DNA gyrase
-
 Streptococcus pyogenes
5.6.2.2 DNA gyrase
-
 Enterococcus faecium
5.6.2.2 DNA gyrase
-
 Bacteroides fragilis
5.6.2.2 DNA gyrase
-
 Moraxella catarrhalis
5.6.2.2 DNA gyrase
-
 Staphylococcus epidermidis
5.6.2.2 DNA gyrase
-
 Citrobacter freundii
5.6.2.2 DNA gyrase
-
 Clostridium perfringens
5.6.2.2 DNA gyrase
-
 Morganella morganii
5.6.2.2 DNA gyrase
-
 Streptococcus agalactiae
5.6.2.2 DNA gyrase
-
 Klebsiella sp.
5.6.2.2 DNA gyrase
-
 Salmonella sp.
5.6.2.2 DNA gyrase
-
 Clostridioides difficile
5.6.2.2 DNA gyrase
-
 Providencia rettgeri
5.6.2.2 DNA gyrase
-
 Bacteroides thetaiotaomicron
5.6.2.2 DNA gyrase
-
 Providencia stuartii
5.6.2.2 DNA gyrase
-
 Listeria monocytogenes
5.6.2.2 DNA gyrase
-
 Shigella sp.
5.6.2.2 DNA gyrase
-
 Enterococcus sp.
5.6.2.2 DNA gyrase
-
 Streptococcus viridans
5.6.2.2 DNA gyrase
-
 Citrobacter spp.
5.6.2.2 DNA gyrase
-
 Legionella sp.
5.6.2.2 DNA gyrase
-
 Prevotella bivia
5.6.2.2 DNA gyrase
-
 Peptostreptococcus sp.

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
5.6.2.2 37
-
 assay at Staphylococcus aureus
5.6.2.2 37
-
 assay at Haemophilus influenzae
5.6.2.2 37
-
 assay at Escherichia coli
5.6.2.2 37
-
 assay at Pseudomonas aeruginosa
5.6.2.2 37
-
 assay at Acinetobacter calcoaceticus
5.6.2.2 37
-
 assay at Serratia marcescens
5.6.2.2 37
-
 assay at Corynebacterium sp.
5.6.2.2 37
-
 assay at Neisseria gonorrhoeae
5.6.2.2 37
-
 assay at Mycobacterium avium
5.6.2.2 37
-
 assay at Streptococcus pneumoniae
5.6.2.2 37
-
 assay at Proteus mirabilis
5.6.2.2 37
-
 assay at Streptococcus pyogenes
5.6.2.2 37
-
 assay at Enterococcus faecium
5.6.2.2 37
-
 assay at Bacteroides fragilis
5.6.2.2 37
-
 assay at Moraxella catarrhalis
5.6.2.2 37
-
 assay at Staphylococcus epidermidis
5.6.2.2 37
-
 assay at Citrobacter freundii
5.6.2.2 37
-
 assay at Clostridium perfringens
5.6.2.2 37
-
 assay at Morganella morganii
5.6.2.2 37
-
 assay at Streptococcus agalactiae
5.6.2.2 37
-
 assay at Klebsiella sp.
5.6.2.2 37
-
 assay at Salmonella sp.
5.6.2.2 37
-
 assay at Clostridioides difficile
5.6.2.2 37
-
 assay at Providencia rettgeri
5.6.2.2 37
-
 assay at Bacteroides thetaiotaomicron
5.6.2.2 37
-
 assay at Providencia stuartii
5.6.2.2 37
-
 assay at Listeria monocytogenes
5.6.2.2 37
-
 assay at Shigella sp.
5.6.2.2 37
-
 assay at Enterococcus sp.
5.6.2.2 37
-
 assay at Streptococcus viridans
5.6.2.2 37
-
 assay at Citrobacter spp.
5.6.2.2 37
-
 assay at Legionella sp.
5.6.2.2 37
-
 assay at Prevotella bivia
5.6.2.2 37
-
 assay at Peptostreptococcus sp.

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
5.6.2.2 6 8 assay at Staphylococcus aureus
5.6.2.2 6 8 assay at Haemophilus influenzae
5.6.2.2 6 8 assay at Escherichia coli
5.6.2.2 6 8 assay at Acinetobacter calcoaceticus
5.6.2.2 6 8 assay at Serratia marcescens
5.6.2.2 6 8 assay at Corynebacterium sp.
5.6.2.2 6 8 assay at Neisseria gonorrhoeae
5.6.2.2 6 8 assay at Mycobacterium avium
5.6.2.2 6 8 assay at Streptococcus pneumoniae
5.6.2.2 6 8 assay at Proteus mirabilis
5.6.2.2 6 8 assay at Streptococcus pyogenes
5.6.2.2 6 8 assay at Enterococcus faecium
5.6.2.2 6 8 assay at Bacteroides fragilis
5.6.2.2 6 8 assay at Moraxella catarrhalis
5.6.2.2 6 8 assay at Staphylococcus epidermidis
5.6.2.2 6 8 assay at Citrobacter freundii
5.6.2.2 6 8 assay at Clostridium perfringens
5.6.2.2 6 8 assay at Morganella morganii
5.6.2.2 6 8 assay at Streptococcus agalactiae
5.6.2.2 6 8 assay at Klebsiella sp.
5.6.2.2 6 8 assay at Salmonella sp.
5.6.2.2 6 8 assay at Clostridioides difficile
5.6.2.2 6 8 assay at Providencia rettgeri
5.6.2.2 6 8 assay at Bacteroides thetaiotaomicron
5.6.2.2 6 8 assay at Providencia stuartii
5.6.2.2 6 8 assay at Listeria monocytogenes
5.6.2.2 6 8 assay at Shigella sp.
5.6.2.2 6 8 assay at Enterococcus sp.
5.6.2.2 6 8 assay at Streptococcus viridans
5.6.2.2 6 8 assay at Citrobacter spp.
5.6.2.2 6 8 assay at Legionella sp.
5.6.2.2 6 8 assay at Prevotella bivia
5.6.2.2 6 8 assay at Peptostreptococcus sp.
5.6.2.2 6 8 assay at, dependent on strain Pseudomonas aeruginosa