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Literature summary extracted from

  • Lo, H.H.; Chung, J.G.
    The effects of plant phenolics, caffeic acid, chlorogenic acid and ferulic acid on arylamine N-acetyltransferase activities in human gastrointestinal microflora (1999), Anticancer Res., 19, 133-139.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.5 caffeic acid 4 mM, 65.3% suppression. Dose-dependent enzyme inhibition in cytosolic and intact cell examinations Citrobacter koseri
2.3.1.5 caffeic acid 4 mM, 37.6% suppression. Dose-dependent enzyme inhibition in cytosolic and intact cell examinations Escherichia coli
2.3.1.5 caffeic acid 4 mM, 37.9% suppression. Dose-dependent enzyme inhibition in cytosolic and intact cell examinations Klebsiella aerogenes
2.3.1.5 caffeic acid 4 mM, 39.7% suppression. Dose-dependent enzyme inhibition in cytosolic and intact cell examinations Klebsiella pneumoniae
2.3.1.5 caffeic acid 4 mM, 83.7% suppression. Dose-dependent enzyme inhibition in cytosolic and intact cell examinations Pseudomonas aeruginosa
2.3.1.5 chlorogenic acid dose-dependent enzyme inhibition in cytosolic and intact cell examinations Citrobacter koseri
2.3.1.5 chlorogenic acid 4mM, significant inhibitory effect for 4 hours. Dose-dependent enzyme inhibition in cytosolic and intact cell examinations Escherichia coli
2.3.1.5 chlorogenic acid dose-dependent enzyme inhibition in cytosolic and intact cell examinations Klebsiella aerogenes
2.3.1.5 chlorogenic acid dose-dependent enzyme inhibition in cytosolic and intact cell examinations Klebsiella pneumoniae
2.3.1.5 chlorogenic acid dose-dependent enzyme inhibition in cytosolic and intact cell examinations Pseudomonas aeruginosa
2.3.1.5 ferulic acid 4 mM, 46.5% suppression. Dose-dependent enzyme inhibition in cytosolic and intact cell examinations Citrobacter koseri
2.3.1.5 ferulic acid 4 mM, 35.8% suppression. Dose-dependent enzyme inhibition in cytosolic and intact cell examinations Escherichia coli
2.3.1.5 ferulic acid 4 mM, 41.4% suppression. Dose-dependent enzyme inhibition in cytosolic and intact cell examinations Klebsiella aerogenes
2.3.1.5 ferulic acid 4 mM, 39.7% suppression. Dose-dependent enzyme inhibition in cytosolic and intact cell examinations Klebsiella pneumoniae
2.3.1.5 ferulic acid 4 mM, 75.1% suppression. Dose-dependent enzyme inhibition in cytosolic and intact cell examinations Pseudomonas aeruginosa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.5 0.00019
-
 2-Aminofluorene
-
 Escherichia coli
2.3.1.5 0.00055
-
 2-Aminofluorene
-
 Pseudomonas aeruginosa

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.5 Citrobacter koseri
-
-
-
2.3.1.5 Escherichia coli
-
-
-
2.3.1.5 Klebsiella aerogenes
-
-
-
2.3.1.5 Klebsiella pneumoniae
-
-
-
2.3.1.5 Pseudomonas aeruginosa
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.5 additional information
-
 Vmax 0.0034 Escherichia coli
2.3.1.5 additional information
-
 Vmax 0.0293 Pseudomonas aeruginosa
2.3.1.5 0.000162
-
 cytosol Escherichia coli
2.3.1.5 0.00068
-
 cytosol Klebsiella pneumoniae
2.3.1.5 0.00478
-
 cytosol Pseudomonas aeruginosa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.5 acetyl-CoA + 2-aminofluorene
-
 Escherichia coli CoA + N-acetyl-2-aminofluorene
-
 ?
2.3.1.5 acetyl-CoA + 2-aminofluorene
-
 Klebsiella aerogenes CoA + N-acetyl-2-aminofluorene
-
 ?
2.3.1.5 acetyl-CoA + 2-aminofluorene
-
 Pseudomonas aeruginosa CoA + N-acetyl-2-aminofluorene
-
 ?
2.3.1.5 acetyl-CoA + 2-aminofluorene
-
 Klebsiella pneumoniae CoA + N-acetyl-2-aminofluorene
-
 ?
2.3.1.5 acetyl-CoA + 2-aminofluorene
-
 Citrobacter koseri CoA + N-acetyl-2-aminofluorene
-
 ?