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Literature summary extracted from

  • Johnson, M.A.; Kuo, Y.M.; Westaway, S.K.; Parker, S.M.; Ching, K.H.; Gitschier, J.; Hayflick, S.J.
    Mitochondrial localization of human PANK2 and hypotheses of secondary iron accumulation in pantothenate kinase-associated neurodegeneration (2004), Ann. N. Y. Acad. Sci., 1012, 282-298.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.33 PANK2, 2 translational strat sites, CAG and CUG initiation codons, expression of PANK2 as EGFP-tagged protein in HeLa cell mitochondria, and in COS-7 cells as His/myc-tagged enzyme Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.33 additional information an allelic variant mislocates and thereby causes disease Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.33 mitochondrion PANK2 contains a mitochondrial targeting signal Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.33 ATP + (R)-pantothenate Homo sapiens
-
 ADP + (R)-4'-phosphopantothenate
-
 ?
2.7.1.33 additional information Homo sapiens naturally occuring pantothenate kinase 2 mutant in patients with neurodegenerative disease in brain with iron accumulation, formerly termed Hallervorden-Spatz disease ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.33 Homo sapiens Q9BZ23 the 5' end of PANK2 gene, Hallervorden-Spatz syndrome, and a CpG island, complete sequence; enzyme form PANK2, 2 allelic variants
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.33 native enzyme partially by preparation of mitochondria Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.33 brain
-
 Homo sapiens
-
2.7.1.33 additional information naturally occuring pantothenate kinase 2 mutant in patients with neurodegenerative disease in brain with iron accumulation, formerly termed Hallervorden-Spatz disease Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.33 ATP + (R)-pantothenate
-
 Homo sapiens ADP + (R)-4'-phosphopantothenate
-
 ?
2.7.1.33 additional information naturally occuring pantothenate kinase 2 mutant in patients with neurodegenerative disease in brain with iron accumulation, formerly termed Hallervorden-Spatz disease Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.33 PanK2
-
 Homo sapiens
2.7.1.33 pantothenate kinase 2
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.33 ATP
-
 Homo sapiens