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Literature summary extracted from

  • Schlossmann, J.; Feil, R.; Hofmann, F.
    Signaling through NO and cGMP-dependent protein kinases (2003), Ann. Med., 35, 21-27.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.12 20 kDa heat shock protein i.e. Hsp20, involved in cGKI-induced smooth muscle relaxation, probably via the actin binding sequence Mammalia
2.7.11.12 cGMP
-
 Mammalia
2.7.11.12 additional information NO induces cGMP production which activates the enzyme Mammalia

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.12 cytosol
-
 Mammalia 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.12 ATP + IRAG Mammalia i.e. inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate, phosphorylation by isoyzme cGKIbeta, which is complexed with the substrate and the inositol 1,4,5-trisphosphate receptor in a ternary complex ADP + phosphorylated IRAG
-
 ?
2.7.11.12 ATP + maxiK channel Mammalia phosphorylation by isoyzme cGKI enhances the channel activity ADP + phosphorylated maxiK channel
-
 ?
2.7.11.12 ATP + myosin phosphatase Mammalia phosphorylation by isoyzme cGKIalpha leads to decreased level of phosphorylated MLC ADP + phosphorylated RhoA
-
 ?
2.7.11.12 ATP + phosphodiesterase 5 Mammalia phosphorylation at Ser92 by isoyzme cGKI leads to enhanced hydrolysis of cGMP, regulatory function ADP + phosphorylated phosphodiesterase 5
-
 ?
2.7.11.12 ATP + RhoA Mammalia phosphorylation at Ser188 by isoyzme cGKI leading to translocation of RhoA from the membrane to the cytosol and inactivates RhoA ADP + phosphorylated RhoA
-
 ?
2.7.11.12 ATP + troponin T Mammalia phosphorylation by isoyzme cGKI in cardiomyocytes ADP + phosphorylated troponin T
-
 ?
2.7.11.12 additional information Mammalia the enzyme activates diverse signal transduction pathways, isozyme cGKI is responsible for smooth muscle relaxation by lowering the cytosolic calcium level and/or by desensitization of the contractile elements, smooth muscle contraction and enzyme-mediated smooth muscle relaxation mechanisms, detailed overview, cGKI affects the Ca2+ efflux from the endoplasmic reticulum and the cytosolic Ca2+ concentration ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.12 Mammalia
-
 isozymes cGKI and cGKII
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.12 cardiomyocyte
-
 Mammalia
-
2.7.11.12 smooth muscle e.g. aortic Mammalia
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.12 ATP + IRAG i.e. inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate, phosphorylation by isoyzme cGKIbeta, which is complexed with the substrate and the inositol 1,4,5-trisphosphate receptor in a ternary complex Mammalia ADP + phosphorylated IRAG
-
 ?
2.7.11.12 ATP + IRAG i.e. inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate, phosphorylation by isoyzme cGKIbeta Mammalia ADP + phosphorylated IRAG
-
 ?
2.7.11.12 ATP + maxiK channel phosphorylation by isoyzme cGKI enhances the channel activity Mammalia ADP + phosphorylated maxiK channel
-
 ?
2.7.11.12 ATP + maxiK channel phosphorylation of the PKC-phosphorylated substrate at Ser1072 by isoyzme cGKI Mammalia ADP + phosphorylated maxiK channel
-
 ?
2.7.11.12 ATP + myosin phosphatase phosphorylation by isoyzme cGKIalpha leads to decreased level of phosphorylated MLC Mammalia ADP + phosphorylated RhoA
-
 ?
2.7.11.12 ATP + myosin phosphatase i.e. MP, phosphorylation of the 130 kDa myosin-binding subunit by isoyzme cGKIalpha Mammalia ADP + phosphorylated RhoA
-
 ?
2.7.11.12 ATP + phosphodiesterase 5 phosphorylation at Ser92 by isoyzme cGKI leads to enhanced hydrolysis of cGMP, regulatory function Mammalia ADP + phosphorylated phosphodiesterase 5
-
 ?
2.7.11.12 ATP + phosphodiesterase 5 phosphorylation at Ser92 by isoyzme cGKI Mammalia ADP + phosphorylated phosphodiesterase 5
-
 ?
2.7.11.12 ATP + RhoA phosphorylation at Ser188 by isoyzme cGKI leading to translocation of RhoA from the membrane to the cytosol and inactivates RhoA Mammalia ADP + phosphorylated RhoA
-
 ?
2.7.11.12 ATP + RhoA phosphorylation at Ser188 by isoyzme cGKI Mammalia ADP + phosphorylated RhoA
-
 ?
2.7.11.12 ATP + troponin T phosphorylation by isoyzme cGKI in cardiomyocytes Mammalia ADP + phosphorylated troponin T
-
 ?
2.7.11.12 ATP + troponin T phosphorylation by isoyzme cGKI Mammalia ADP + phosphorylated troponin T
-
 ?
2.7.11.12 additional information the enzyme activates diverse signal transduction pathways, isozyme cGKI is responsible for smooth muscle relaxation by lowering the cytosolic calcium level and/or by desensitization of the contractile elements, smooth muscle contraction and enzyme-mediated smooth muscle relaxation mechanisms, detailed overview, cGKI affects the Ca2+ efflux from the endoplasmic reticulum and the cytosolic Ca2+ concentration Mammalia ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.12 CGK
-
 Mammalia

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.12 ATP
-
 Mammalia