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Literature summary extracted from

  • Lewin, T.M.; Wang, S.; Nagle, C.A.; Van Horn, C.G.; Coleman, R.A.
    Mitochondrial glycerol-3-phosphate acyltransferase-1 directs the metabolic fate of exogenous fatty acids in hepatocytes (2005), Am. J. Physiol., 288, E835-844.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.15 overexpression of FLAG-tagged mitochondrial isozymes in HEK293 cells and in primary hepatocytes from fasted rats via adenovirus transfection system, leading to increased enzyme activity and incorporation of added oleate into triacylglycerol, the triacylgycerol is secreted from the recombinant hepatocytes if higher concentrated, phospholipid composition in hepatocytes, overview Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.15 mitochondrion mitochondrial isozyme Rattus norvegicus 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.3.1.15 Mg2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.15 acyl-CoA + sn-glycerol 3-phosphate Rattus norvegicus the enzyme catalyzes the first and committed step in the synthesis of glycerophospholipids and TAG from sn-glycerol-3-phosphate CoA + 1-acyl-sn-glycerol 3-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.15 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.15 hepatocyte
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.15 acyl-CoA + sn-glycerol 3-phosphate
-
 Rattus norvegicus CoA + 1-acyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.15 acyl-CoA + sn-glycerol 3-phosphate the enzyme catalyzes the first and committed step in the synthesis of glycerophospholipids and TAG from sn-glycerol-3-phosphate Rattus norvegicus CoA + 1-acyl-sn-glycerol 3-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.15 glycerol-3-phosphate acyltransferase-1
-
 Rattus norvegicus
2.3.1.15 mtGPAT
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.15 22
-
 assay at room temperature Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.15 7.5
-
 assay at Rattus norvegicus