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Literature summary extracted from

  • Brown, K.L.; Morris, V.K.; Izard, T.
    Rhombohedral crystals of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase (2004), Acta Crystallogr. Sect. D, 60, 195-196.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.7.3 drug development potential target for antibiotic drugs Mycobacterium tuberculosis

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.3 expressed in Escherichia coli BL21(DE3) Mycobacterium tuberculosis

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.7.7.3 hanging drop vapor diffusion method Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.3 ATP + pantetheine 4'-phosphate Mycobacterium tuberculosis rate-limiting penultimate step in coenzyme A biosynthesis diphosphate + 3'-dephospho-CoA
-
 r
2.7.7.3 ATP + pantetheine 4'-phosphate Mycobacterium tuberculosis Rv2965c rate-limiting penultimate step in coenzyme A biosynthesis diphosphate + 3'-dephospho-CoA
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.3 Mycobacterium tuberculosis
-
-
-
2.7.7.3 Mycobacterium tuberculosis Rv2965c
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.7.3
-
 Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.3 ATP + pantetheine 4'-phosphate
-
 Mycobacterium tuberculosis diphosphate + 3'-dephospho-CoA
-
 r
2.7.7.3 ATP + pantetheine 4'-phosphate rate-limiting penultimate step in coenzyme A biosynthesis Mycobacterium tuberculosis diphosphate + 3'-dephospho-CoA
-
 r
2.7.7.3 ATP + pantetheine 4'-phosphate
-
 Mycobacterium tuberculosis Rv2965c diphosphate + 3'-dephospho-CoA
-
 r
2.7.7.3 ATP + pantetheine 4'-phosphate rate-limiting penultimate step in coenzyme A biosynthesis Mycobacterium tuberculosis Rv2965c diphosphate + 3'-dephospho-CoA
-
 r

Synonyms

EC Number Synonyms Comment Organism
2.7.7.3 More bifunctional enzyme catalyzing the last two steps of coenzyme A biosynthesis Mycobacterium tuberculosis