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Literature summary extracted from

  • van Duursen, M.B.; Sanderson, J.T.; de Jong, P.C.; Kraaij, M.; van den Berg, M.
    Phytochemicals inhibit catechol-O-methyltransferase activity in cytosolic fractions from healthy human mammary tissues: implications for catechol estrogen-induced DNA damage (2004), Toxicol. Sci., 81, 316-324.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.6 catechin IC50: 0.00164 mM Homo sapiens
2.1.1.6 chrysin slight inhibition at 0.3 mM Homo sapiens
2.1.1.6 epicatechin IC50: 0.00196 mM Homo sapiens
2.1.1.6 flavone IC50: 0.00549 mM Homo sapiens
2.1.1.6 genistein slight inhibition at 0.3 mM Homo sapiens
2.1.1.6 quercetin IC50: 0.00048 mM Homo sapiens
2.1.1.6 Ro 41-0960 IC50: 5-42 nM Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.6 additional information Homo sapiens the enzyme plays an important role in the inactivation potentially genotoxic catechol estrogens ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.6 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.6 mammary gland healthy Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.6 additional information the enzyme plays an important role in the inactivation potentially genotoxic catechol estrogens Homo sapiens ?
-
 ?
2.1.1.6 S-adenosyl-L-methionine + 2-hydroxyestradiol
-
 Homo sapiens S-adenosyl-L-homocysteine + ?
-
 ?
2.1.1.6 S-adenosyl-L-methionine + 4-hydroxyestradiol
-
 Homo sapiens S-adenosyl-L-homocysteine + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.6 COMT
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.1.1.6 0.000005 0.000042 IC50: 5-42 nM Homo sapiens Ro 41-0960
2.1.1.6 0.00048
-
 IC50: 0.00048 mM Homo sapiens quercetin
2.1.1.6 0.00164
-
 IC50: 0.00164 mM Homo sapiens catechin
2.1.1.6 0.00196
-
 IC50: 0.00196 mM Homo sapiens epicatechin
2.1.1.6 0.00549
-
 IC50: 0.00549 mM Homo sapiens flavone