Literature summary extracted from

Zhang, X.; Beaulieu, J.M.; Sotnikova, T.D.; Gainetdinov, R.R.; Caron, M.G.
Tryptophan hydroxylase-2 controls brain serotonin synthesis (2004), Science, 305, 217.

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.14.16.4	L-tryptophan + tetrahydropteridine + O2	Mus musculus	tryptophan hydroxylase-2 controls brain serotonin synthesis	5-hydroxy-L-tryptophan + dihydropteridine + H2O	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.14.16.4	Mus musculus	Q8CGV2	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.14.16.4	brain	-	Mus musculus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.14.16.4	L-tryptophan + tetrahydropteridine + O2	tryptophan hydroxylase-2 controls brain serotonin synthesis	Mus musculus	5-hydroxy-L-tryptophan + dihydropteridine + H2O	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.14.16.4	tryptophan hydroxylase-2	-	Mus musculus

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Release 2023.1 (January 2023)