Literature summary extracted from

Kim, S.; Takahashi, M.; Higuchi, K.; Tsunoda, K.; Nakanishi, H.; Yoshimura, E.; Mori, S.; Nishizawa, N.K.
Increased nicotianamine biosynthesis confers enhanced tolerance of high levels of metals, in particular nickel, to plants (2005), Plant Cell Physiol., 46, 1809-1818.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
2.5.1.43	transgenic Arabidopsis and tobacco plants constitutively overexpress the enzyme from Hordeum vulgare. Nicotianamine synthase overexpression results in increased biosynthesis of nicotianamine in transgenic plants, which conferrs enhanced tolerance of high levels of metals, particularly nickel, to plants. Promoter activities of four nicotianamine synthase genes in Arabidopsis are all increased in response to excess nickel, suggesting that nicotianamine plays an important role in the detoxification of nickel in plants. Transgenic tobacco plants with a high level of nicotianamine grew well in a nickel-enriched serpentine soil without developing any symptoms of nickel toxicity	Hordeum vulgare

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.5.1.43	S-adenosyl-L-methionine	Hordeum vulgare	the product nictotinamine plays a critical role in metal detoxification	5'-S-methyl-5'-thioadenosine + nicotianamine	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.5.1.43	Hordeum vulgare	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.5.1.43	S-adenosyl-L-methionine	the product nictotinamine plays a critical role in metal detoxification	Hordeum vulgare	5'-S-methyl-5'-thioadenosine + nicotianamine	-	?

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)