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Literature summary extracted from

  • Schneider, I.; Bucar, F.
    Lipoxygenase inhibitors from natural plant sources. Part 1: Medicinal plants with inhibitory activity on arachidonate 5-lipoxygenase and 5-lipoxygenase/cyclooxygenase (2005), Phytother. Res., 19, 81-102.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.34 (-)-epicatechin
-
Homo sapiens
1.13.11.34 11alpha,13-dihydrohelenalin acetate enzyme from polymorphonuclear leukocyte Homo sapiens
1.13.11.34 2,3,4',5-tetrahydroxystilbene-2-O-D-glucoside polymorphonuclear leukocyte Rattus norvegicus
1.13.11.34 4-methylesculetin polymorphonuclear leukocyte Rattus norvegicus
1.13.11.34 beta-hydroxyacteoside enzyme from polymorphonuclear leukocyte Homo sapiens
1.13.11.34 capsaicin enzyme from polymorphonuclear leukocyte Homo sapiens
1.13.11.34 daphnetin polymorphonuclear leukocyte Rattus norvegicus
1.13.11.34 esculetin polymorphonuclear leukocyte Rattus norvegicus
1.13.11.34 falcarindiol
-
Sus scrofa
1.13.11.34 forsythiaside enzyme from polymorphonuclear leukocyte Homo sapiens
1.13.11.34 forsythiaside polymorphonuclear leukocyte Rattus norvegicus
1.13.11.34 fraxetin polymorphonuclear leukocyte Rattus norvegicus
1.13.11.34 gingerdione enzyme from polymorphonuclear leukocyte Homo sapiens
1.13.11.34 helenalin enzyme from polymorphonuclear leukocyte Homo sapiens
1.13.11.34 isoriccardin C
-
Sus scrofa
1.13.11.34 leucocyanidol polymorphonuclear leukocyte Rattus norvegicus
1.13.11.34 marchantin A
-
Sus scrofa
1.13.11.34 marchantin B
-
Sus scrofa
1.13.11.34 marchantin D
-
Sus scrofa
1.13.11.34 marchantin E
-
Sus scrofa
1.13.11.34 additional information plant extracts with inhibitory activity on arachidonate 5-lipoxygenase, inhibition of the 5-lipoxygenase pathway is considered to be interesting in the treatment of a variety of inflammatory diseases Bos taurus
1.13.11.34 additional information plant extracts with inhibitory activity on arachidonate 5-lipoxygenase, inhibition of the 5-lipoxygenase pathway is considered to be interesting in the treatment of a variety of inflammatory diseases. Cavia porcellus
1.13.11.34 additional information plant extracts with inhibitory activity on arachidonate 5-lipoxygenase, inhibition of the 5-lipoxygenase pathway is considered to be interesting in the treatment of a variety of inflammatory diseases. Glycine max
1.13.11.34 additional information plant extracts with inhibitory activity on arachidonate 5-lipoxygenase, inhibition of the 5-lipoxygenase pathway is considered to be interesting in the treatment of a variety of inflammatory diseases. Helianthus tuberosus
1.13.11.34 additional information plant extracts with inhibitory activity on arachidonate 5-lipoxygenase, inhibition of the 5-lipoxygenase pathway is considered to be interesting in the treatment of a variety of inflammatory diseases. Mus musculus
1.13.11.34 additional information plant extracts with inhibitory activity on arachidonate 5-lipoxygenase, inhibition of the 5-lipoxygenase pathway is considered to be interesting in the treatment of a variety of inflammatory diseases. Rattus norvegicus
1.13.11.34 additional information plant extracts with inhibitory activity on arachidonate 5-lipoxygenase, inhibition of the 5-lipoxygenase pathway is considered to be interesting in the treatment of a variety of inflammatory diseases. Sus scrofa
1.13.11.34 myrtol enzyme from RBL-1 cell Rattus norvegicus
1.13.11.34 oroxindin polymorphonuclear leukocyte Rattus norvegicus
1.13.11.34 paleatin B
-
Sus scrofa
1.13.11.34 panaxynol
-
Sus scrofa
1.13.11.34 perrottetin D
-
Sus scrofa
1.13.11.34 piceid polymorphonuclear leukocyte Rattus norvegicus
1.13.11.34 quercetagetin-7-O-beta-D-glucoside polymorphonuclear leukocyte Rattus norvegicus
1.13.11.34 radulanin H
-
Sus scrofa
1.13.11.34 resveratrol polymorphonuclear leukocyte Rattus norvegicus
1.13.11.34 shogaol enzyme from polymorphonuclear leukocyte Homo sapiens
1.13.11.34 sideritoflavone polymorphonuclear leukocyte Rattus norvegicus
1.13.11.34 suspensaside enzyme from polymorphonuclear leukocyte Homo sapiens
1.13.11.34 suspensaside polymorphonuclear leukocyte Rattus norvegicus
1.13.11.34 tambuletin polymorphonuclear leukocyte Rattus norvegicus
1.13.11.34 verbascoside enzyme from polymorphonuclear leukocyte Homo sapiens
1.13.11.34 verbascoside polymorphonuclear leukocyte Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.34 additional information Cavia porcellus key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions ?
-
?
1.13.11.34 additional information Mus musculus key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions ?
-
?
1.13.11.34 additional information Homo sapiens key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions ?
-
?
1.13.11.34 additional information Rattus norvegicus key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions ?
-
?
1.13.11.34 additional information Sus scrofa key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions ?
-
?
1.13.11.34 additional information Bos taurus key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions ?
-
?
1.13.11.34 additional information Glycine max key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions ?
-
?
1.13.11.34 additional information Helianthus tuberosus key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.34 Bos taurus
-
-
-
1.13.11.34 Cavia porcellus
-
-
-
1.13.11.34 Glycine max
-
-
-
1.13.11.34 Helianthus tuberosus
-
-
-
1.13.11.34 Homo sapiens
-
-
-
1.13.11.34 Mus musculus
-
-
-
1.13.11.34 Rattus norvegicus
-
-
-
1.13.11.34 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.34 bone marrow
-
Homo sapiens
-
1.13.11.34 granulocyte
-
Homo sapiens
-
1.13.11.34 leukocyte
-
Sus scrofa
-
1.13.11.34 macrophage
-
Homo sapiens
-
1.13.11.34 mast cell
-
Rattus norvegicus
-
1.13.11.34 neutrophil
-
Homo sapiens
-
1.13.11.34 polymorphonuclear leukocyte
-
Homo sapiens
-
1.13.11.34 polymorphonuclear leukocyte
-
Rattus norvegicus
-
1.13.11.34 polymorphonuclear leukocyte
-
Bos taurus
-
1.13.11.34 polymorphonuclear leukocyte peritoneal Cavia porcellus
-
1.13.11.34 polymorphonuclear leukocyte peritoneal Mus musculus
-
1.13.11.34 RBL-1 cell basophilic leukemia cell Rattus norvegicus
-
1.13.11.34 seedling
-
Helianthus tuberosus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.34 additional information key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions Cavia porcellus ?
-
?
1.13.11.34 additional information key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions Mus musculus ?
-
?
1.13.11.34 additional information key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions Homo sapiens ?
-
?
1.13.11.34 additional information key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions Rattus norvegicus ?
-
?
1.13.11.34 additional information key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions Sus scrofa ?
-
?
1.13.11.34 additional information key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions Bos taurus ?
-
?
1.13.11.34 additional information key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions Glycine max ?
-
?
1.13.11.34 additional information key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions Helianthus tuberosus ?
-
?