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Literature summary extracted from

  • Heiss, C.; Anderson, J.; Phillips, R.S.
    Differential effects of bromination on substrates and inhibitors of kynureninase from Pseudomonas fluorescens (2003), Org. Biomol. Chem., 1, 288-295.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.7.1.3 (4R)-5-bromodihydro-L-kynurenine
-
 Pseudomonas fluorescens
3.7.1.3 (4S)-5-bromodihydro-L-kynurenine
-
 Pseudomonas fluorescens
3.7.1.3 (S)-(2-amino-4-bromophenyl)-L-cysteine S,S-dioxide competitive inhibition Pseudomonas fluorescens
3.7.1.3 (S)-(2-amino-5-bromophenyl)-L-cysteine S,S-dioxide competitive inhibition Pseudomonas fluorescens
3.7.1.3 (S)-(2-aminophenyl)-L-cysteine S,S-dioxide
-
 Pseudomonas fluorescens
3.7.1.3 dihydro-L-kynurenine
-
 Pseudomonas fluorescens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.7.1.3 0.011
-
 5-bromo-L-kynurenine
-
 Pseudomonas fluorescens
3.7.1.3 0.025
-
 L-kynurenine
-
 Pseudomonas fluorescens
3.7.1.3 2
-
 3-bromo-L-kynurenine
-
 Pseudomonas fluorescens

Organism

EC Number Organism UniProt Comment Textmining
3.7.1.3 Pseudomonas fluorescens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.7.1.3 no modification
-
 Pseudomonas fluorescens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.7.1.3 (4R)-5-bromodihydro-L-kynurenine + H2O slow substrate, no activity with (4S)-5-bromodihydro-L-kynurenine Pseudomonas fluorescens ? + L-alanine
-
 ?
3.7.1.3 3-bromo-L-kynurenine + H2O
-
 Pseudomonas fluorescens 3-bromoanthranilate + L-alanine
-
 ?
3.7.1.3 5-bromo-L-kynurenine + H2O
-
 Pseudomonas fluorescens 5-bromoanthranilate + L-alanine
-
 ?
3.7.1.3 L-kynurenine + H2O
-
 Pseudomonas fluorescens anthranilate + L-alanine
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.7.1.3 0.000027
-
 (S)-(2-aminophenyl)-L-cysteine S,S-dioxide
-
 Pseudomonas fluorescens
3.7.1.3 0.000055
-
 (4R)-5-bromodihydro-L-kynurenine
-
 Pseudomonas fluorescens
3.7.1.3 0.00017
-
 (4S)-5-bromodihydro-L-kynurenine
-
 Pseudomonas fluorescens
3.7.1.3 0.0003
-
 (S)-(2-amino-4-bromophenyl)-L-cysteine S,S-dioxide
-
 Pseudomonas fluorescens
3.7.1.3 0.0004
-
 (S)-(2-amino-5-bromophenyl)-L-cysteine S,S-dioxide
-
 Pseudomonas fluorescens