Literature summary extracted from

Ma, J.F.; Nonn, L.; Campbell, M.J.; Hewison, M.; Feldman, D.; Peehl, D.M.
Mechanisms of decreased Vitamin D 1alpha-hydroxylase activity in prostate cancer cells (2004), Mol. Cell. Endocrinol., 221, 67-74.

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
1.14.15.18	mitochondrion	-	Homo sapiens	5739	-

Molecular Weight [Da]

EC Number	Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
1.14.15.18	56000	-	SDS-PAGE	Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.14.15.18	25-hydroxyvitamin D3 + NADPH + O2	Homo sapiens	final step of the activation of vitamin D, involved in tumor suppressing activity due to the tumor growth inhibiting effect of 1alpha,25-dihydroxyvitamin D3	1alpha,25-dihydroxyvitamin D3 + NADP+ + H2O	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.14.15.18	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.14.15.18	DU-145 cell	prostate cancer cell line, greatly decreased activity of 25-hydroxyvitamin D-1alpha-hydroxylase due to decreased RNA transcription	Homo sapiens	-
1.14.15.18	kidney	-	Homo sapiens	-
1.14.15.18	LNCaP cell	prostate cancer cell line, greatly decreased activity of 25-hydroxyvitamin D-1alpha-hydroxylase due to decreased RNA transcription	Homo sapiens	-
1.14.15.18	PC-3 cell	prostate cancer cell line, greatly decreased activity of 25-hydroxyvitamin D-1alpha-hydroxylase due to decreased RNA transcription	Homo sapiens	-
1.14.15.18	prostate	tissue obtained from normal prostate, benign prostatic hyperplastia or cancer, primary and cultured prostate cancer cells have greatly decreased activity of 25-hydroxyvitamin D-1alpha-hydroxylase and are therefore resistant to the tumor suppressing activity of circulating 25-hydroxyvitamin D3	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.14.15.18	25-hydroxyvitamin D3 + NADPH + O2	-	Homo sapiens	1alpha,25-dihydroxyvitamin D3 + NADP+ + H2O	-	?
1.14.15.18	25-hydroxyvitamin D3 + NADPH + O2	final step of the activation of vitamin D, involved in tumor suppressing activity due to the tumor growth inhibiting effect of 1alpha,25-dihydroxyvitamin D3	Homo sapiens	1alpha,25-dihydroxyvitamin D3 + NADP+ + H2O	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.14.15.18	25-hydroxyvitamin D-1alpha-hydroxylase	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)