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Literature summary extracted from

  • Taipale, M.; Rea, S.; Richter, K.; Vilar, A.; Lichter, P.; Imhof, A.; Akhtar, A.
    hMOF histone acetyltransferase is required for histone H4 lysine 16 acetylation in mammalian cells (2005), Mol. Cell. Biol., 25, 6798-6810.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.48 acetyl-CoA + histone H4 Homo sapiens specific acetylation of Lys16, reversible acetylation of histones play an important role in regulation of chromatin structure and function. HMOF has a role in DNA damage responseduring cell cycle progression CoA + acetylhistone H4
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.48 Homo sapiens
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-
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.48 HeLa cell
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 Homo sapiens
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2.3.1.48 Hep-G2 cell
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 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.48 acetyl-CoA + histone H4 specific acetylation of Lys16, reversible acetylation of histones play an important role in regulation of chromatin structure and function. HMOF has a role in DNA damage responseduring cell cycle progression Homo sapiens CoA + acetylhistone H4
-
 ?
2.3.1.48 acetyl-CoA + histone H4 specific acetylation of Lys16 Homo sapiens peptide CoA + acetylhistone H4 peptide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.48 hMOF
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 Homo sapiens