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Literature summary extracted from

  • Stadtman, E.R.; Moskovitz, J.; Berlett, B.S.; Levine, R.L.
    Cyclic axidation and reduction of protein methionine residues is an important antioxidant mechanism (2002), Mol. Cell. Biochem., 2347235, 3-9.
No PubMed abstract available

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.4.11 L-methionine (S)-sulfoxide + thioredoxin Saccharomyces cerevisiae MsrA is specific for the S-form of the substrate L-methionine + thioredoxin disulfide + H2O
-
 ?
1.8.4.11 additional information Saccharomyces cerevisiae protection of the cells against reactive oxidizing species, biological consequences of methionine oxidation, physiological role, overview ?
-
 ?
1.8.4.12 L-methionine (R)-sulfoxide + thioredoxin Mus musculus MsrB is specific for the R-form of the substrate L-methionine + thioredoxin disulfide + H2O
-
 ir
1.8.4.12 additional information Mus musculus protection of the cells against reactive oxidizing species, biological consequences of methionine oxidation, physiological role, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.4.11 Saccharomyces cerevisiae
-
-
-
1.8.4.12 Mus musculus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.4.11 L-methionine (S)-sulfoxide + thioredoxin MsrA is specific for the S-form of the substrate Saccharomyces cerevisiae L-methionine + thioredoxin disulfide + H2O
-
 ?
1.8.4.11 additional information protection of the cells against reactive oxidizing species, biological consequences of methionine oxidation, physiological role, overview Saccharomyces cerevisiae ?
-
 ?
1.8.4.12 L-methionine (R)-sulfoxide + thioredoxin MsrB is specific for the R-form of the substrate Mus musculus L-methionine + thioredoxin disulfide + H2O
-
 ir
1.8.4.12 additional information protection of the cells against reactive oxidizing species, biological consequences of methionine oxidation, physiological role, overview Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.4.11 methionine sulfoxide reductase
-
 Saccharomyces cerevisiae
1.8.4.11 MsrA
-
 Saccharomyces cerevisiae
1.8.4.12 methionine sulfoxide reductase
-
 Mus musculus
1.8.4.12 MsrB
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.4.11 thioredoxin dependent on Saccharomyces cerevisiae
1.8.4.12 thioredoxin dependent on Mus musculus