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Literature summary extracted from

  • Zarella-Boitz, J.M.; Rager, N.; Jardim, A.; Ullman, B.
    Subcellular localization of adenine and xanthine phosphoribosyltransferases in Leishmania donovani (2004), Mol. Biochem. Parasitol., 134, 43-51.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.2.7
-
 Leishmania donovani
2.4.2.22 expression of full length and C-terminally truncated enzymes in Escherichia coli Leishmania donovani

Protein Variants

EC Number Protein Variants Comment Organism
2.4.2.22 additional information deletion of the glycosomal targeting sequence, a C-terminal tripeptide, leads to mislocation of the enzyme in the cytosol, where the enzyme nevertheless is still active Leishmania donovani

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.2.7 cytosol
-
 Leishmania donovani 5829
-
2.4.2.22 glycosome deletion of the glycosomal targeting sequence, a C-terminal tripeptide, leads to mislocation of the enzyme in the cytosol, where the enzyme nevertheless is still active Leishmania donovani 20015
-
2.4.2.22 additional information immunohistologic subcellular localization study Leishmania donovani
-
-
2.4.2.22 peroxisome deletion of the peroxisomal targeting sequence is not required for activity Leishmania donovani 5777
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.22 5-phospho-alpha-D-ribose 1-diphosphate + xanthine Leishmania donovani the enzyme is involved in purine nucleotide synthesis via phosphorylation of purines acquisited from the host, since Leishmania donovani is not able to perform de novo biosynthesis of purine nucleotides 9-(5-phospho-beta-D-ribosyl)xanthine + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.7 Leishmania donovani
-
-
-
2.4.2.22 Leishmania donovani
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.2.22 recombinant full length and C-terminally truncated enzymes from Escherichia coli by affinity chromatography Leishmania donovani

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.7 promastigote
-
 Leishmania donovani
-
2.4.2.22 promastigote
-
 Leishmania donovani
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.22 5-phospho-alpha-D-ribose 1-diphosphate + xanthine
-
 Leishmania donovani 9-(5-phospho-beta-D-ribosyl)xanthine + diphosphate
-
 ?
2.4.2.22 5-phospho-alpha-D-ribose 1-diphosphate + xanthine the enzyme is involved in purine nucleotide synthesis via phosphorylation of purines acquisited from the host, since Leishmania donovani is not able to perform de novo biosynthesis of purine nucleotides Leishmania donovani 9-(5-phospho-beta-D-ribosyl)xanthine + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.7 APRT
-
 Leishmania donovani
2.4.2.22 xanthine PRT
-
 Leishmania donovani
2.4.2.22 XPRT
-
 Leishmania donovani