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Literature summary extracted from
- Purification and properties of pantetheinase from horse kidney (1979), Methods Enzymol., 62, 262-267.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.5.1.92 | 2-mercaptoethanol | activates | Equus caballus |  |
| 3.5.1.92 | dithiothreitol | activates | Equus caballus | |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.5.1.92 | cysteamine | 5 mM, 55% inhibition | Equus caballus | |
| 3.5.1.92 | iodoacetamide | at high concentrations | Equus caballus | |
| 3.5.1.92 | iodoacetate | at high concentrations | Equus caballus | |
| 3.5.1.92 | NaN3 | 15 mM, 90% inhibition | Equus caballus | |
| 3.5.1.92 | pantothenate | 50 mM, 60% inhibition | Equus caballus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.5.1.92 | 5 | - |
pantetheine | - |
Equus caballus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.5.1.92 | 55000 | - |
ultracentrifugation | Equus caballus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.5.1.92 | Equus caballus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.5.1.92 | - |
Equus caballus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.5.1.92 | heart | - |
Equus caballus | - |
| 3.5.1.92 | kidney | - |
Equus caballus | - |
| 3.5.1.92 | liver | - |
Equus caballus | - |
| 3.5.1.92 | muscle | - |
Equus caballus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.5.1.92 | 0.4 | - |
- |
Equus caballus |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 3.5.1.92 | -20°C, pH 7, several months without significant loss of activity | Equus caballus |
| 3.5.1.92 | 0°C, dilute solutions lose 5% activity per week | Equus caballus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.1.92 | (R)-pantetheine + H2O | - |
Equus caballus | (R)-pantothenate + cysteamine | - |
? | |
| 3.5.1.92 | (R)-pantetheine 4-phosphate + H2O | 10% of the activity with (R)-pantetheine | Equus caballus | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.5.1.92 | pantetheinase | - |
Equus caballus |
| 3.5.1.92 | pantetheine hydrolase | - |
Equus caballus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.5.1.92 | 4 | 5.5 | - |
Equus caballus |
pH Stability
| EC Number | pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.5.1.92 | 5 | 7.6 | good stability, rapid decrease outside this range | Equus caballus |
pI Value
| EC Number | Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|---|
| 3.5.1.92 | Equus caballus | - |
- |
4.8 |
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Release 2023.1 (January 2023)
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