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Literature summary extracted from

  • Schachter, H.; Reck, F.; Paulsen, H.
    Use of synthetic oligosaccharide substrate analogs to map the active sites of N-acetylglucosaminyltransferases I and II (2003), Methods Enzymol., 363, 459-475.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.101 Manalpha6(6-O-(4,4-azopentyl)-Manalpha3)Man-beta-octyl
-
 Rattus norvegicus
2.4.1.101 Manalpha6(6-O-(4,5-epoxypentyl)-Manalpha3)Man-beta-octyl
-
 Rattus norvegicus
2.4.1.101 Manalpha6(6-O-(4-oxopentyl)-Manalpha3)Man-beta-octyl
-
 Rattus norvegicus
2.4.1.101 Manalpha6(6-O-(5-pentanolyl)-Manalpha3)Man-beta-octyl
-
 Rattus norvegicus
2.4.1.101 Manalpha6(6-O-methyl-Manalpha3)Man-beta-octyl
-
 Rattus norvegicus
2.4.1.101 [Manalpha6(Manalpha3)][4-O-methyl-Man]-beta4-N-acetyl-D-glucosamine
-
 Rattus norvegicus
2.4.1.143 2-deoxy-Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Man-beta-octyl
-
 Homo sapiens
2.4.1.143 3-O-(4,4-azopentyl)-Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Man-beta-octyl
-
 Homo sapiens
2.4.1.143 3-O-(5-aminopentyl)-Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Man-beta-octyl
-
 Homo sapiens
2.4.1.143 3-O-pentyl-Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Man-beta-octyl
-
 Homo sapiens
2.4.1.143 GlcNAcbeta(1-2)Manalpha(1-3)Man-beta-octyl
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.101 0.3
-
 6-O-methyl-Manalpha6(Manalpha3)Man-beta-octyl
-
 Rattus norvegicus
2.4.1.101 0.4
-
 [Manalpha6(Manalpha3)Manalpha6][Manalpha3]Man-beta4-N-acetyl-D-glucosamine-beta4-N-acetyl-D-glucosamine-Asn
-
 Rattus norvegicus
2.4.1.101 0.4
-
 Manalpha6(Manalpha3)Man-O-beta4-N-acetyl-D-glucosamine-beta4(L-fucose-alpha6)-N-acetyl-D-glucosamine-Asn
-
 Rattus norvegicus
2.4.1.101 0.6
-
 2-deoxy-Manalpha6(Manalpha3)Man-beta-octyl
-
 Rattus norvegicus
2.4.1.101 0.7
-
 Manalpha6(Manalpha3)Man-O-beta-octyl
-
 Rattus norvegicus
2.4.1.101 0.9
-
 4-O-methyl-Manalpha6(Manalpha3)Man-beta-octyl
-
 Rattus norvegicus
2.4.1.101 1.2
-
 3-O-(4,4-azopentyl)-Manalpha6(Manalpha3)Man-beta-octyl
-
 Rattus norvegicus
2.4.1.101 1.4
-
 3-O-(5-iodoacetamidopentyl)-Manalpha6(Manalpha3)Man-beta-octyl
-
 Rattus norvegicus
2.4.1.101 1.5
-
 Manalpha6(Manalpha3)Man-O-beta(8-methoxycarbonyl)octyl
-
 Rattus norvegicus
2.4.1.101 1.7
-
 Manalpha6(Manalpha3)Man-O-beta hexyl
-
 Rattus norvegicus
2.4.1.101 1.8
-
 Manalpha6(Manalpha3)Man-O-beta4-N-acetyl-D-glucosamine-beta4-N-acetyl-D-glucosamine
-
 Rattus norvegicus
2.4.1.101 1.8
-
 3-O-(4,5-epoxypentyl)-Manalpha6(Manalpha3)Man-beta-octyl
-
 Rattus norvegicus
2.4.1.101 1.9
-
 N-acetyl-D-glucosamine-beta2-Manalpha6(Manalpha3)Man-beta4-N-acetyl-D-glucosamine
-
 Rattus norvegicus
2.4.1.101 2.6
-
 Manalpha6(4-O-methyl-Manalpha3)Man-beta-octyl
-
 Rattus norvegicus
2.4.1.101 2.7
-
 Manalpha6(Manalpha3)Man-O-beta4-N-acetyl-D-glucosamine
-
 Rattus norvegicus
2.4.1.101 3.5
-
 3-O-pentyl-Manalpha6(Manalpha3)Man-beta-octyl
-
 Rattus norvegicus
2.4.1.101 4.5
-
 Manalpha6(Manalpha3)Man-O-beta4-N-acetyl-D-glucosamine
-
 Rattus norvegicus
2.4.1.101 5
-
 Manalpha6(4-O-(5-iodoacetamidopentyl)-Manalpha3)Man-beta-octyl
-
 Rattus norvegicus
2.4.1.101 22
-
 Manalpha6(4-deoxy-Manalpha3)Man-beta-octyl
-
 Rattus norvegicus
2.4.1.143 0.13
-
 Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta-octyl
-
 Homo sapiens
2.4.1.143 0.16
-
 Manalpha(1-6)(GlcNAcbeta(1-2)4-O-methyl-Manalpha(1-3))Manbeta-octyl
-
 Homo sapiens
2.4.1.143 0.2
-
 6-O-methyl-Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta-octyl
-
 Homo sapiens
2.4.1.143 0.22
-
 4-deoxy-Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta-octyl
-
 Homo sapiens
2.4.1.143 0.25
-
 6-deoxy-Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta-octyl
-
 Homo sapiens
2.4.1.143 0.26
-
 3-O-methyl-Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta-octyl
-
 Homo sapiens
2.4.1.143 0.26
-
 4-O-methyl-Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta-octyl
-
 Homo sapiens
2.4.1.143 0.48
-
 Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))-4-deoxy-Manbeta-octyl
-
 Homo sapiens
2.4.1.143 0.55
-
 Manalpha(1-6)(GlcNAcbeta(1-2)-6-deoxy-Manalpha(1-3))Manbeta-octyl
-
 Homo sapiens
2.4.1.143 3.7
-
 3-deoxy-Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta-octyl
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.101 Rattus norvegicus
-
-
-
2.4.1.143 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.101 UDP + [Manalpha6(Manalpha3)Manalpha6][Manalpha3]Man-beta4-N-acetyl-D-glucosamine-beta4-N-acetyl-D-glucosamine-Asn
-
 Rattus norvegicus ?
-
 ?
2.4.1.101 UDP-N-acetyl-D-glucosamine + 2-deoxy-Manalpha6(Manalpha3)Man-beta-octyl
-
 Rattus norvegicus UDP + ?
-
 ?
2.4.1.101 UDP-N-acetyl-D-glucosamine + 3-O-(4,4-azopentyl)-Manalpha6(Manalpha3)Man-beta-octyl
-
 Rattus norvegicus UDP + ?
-
 ?
2.4.1.101 UDP-N-acetyl-D-glucosamine + 3-O-(4,5-epoxypentyl)-Manalpha6(Manalpha3)Man-beta-octyl
-
 Rattus norvegicus UDP + ?
-
 ?
2.4.1.101 UDP-N-acetyl-D-glucosamine + 3-O-(5-iodoacetamidopentyl)-Manalpha6(Manalpha3)Man-beta-octyl
-
 Rattus norvegicus UDP + ?
-
 ?
2.4.1.101 UDP-N-acetyl-D-glucosamine + 3-O-pentyl-Manalpha6(Manalpha3)Man-beta-octyl
-
 Rattus norvegicus UDP + ?
-
 ?
2.4.1.101 UDP-N-acetyl-D-glucosamine + 4-O-methyl-Manalpha6(Manalpha3)Man-beta-octyl
-
 Rattus norvegicus UDP + ?
-
 ?
2.4.1.101 UDP-N-acetyl-D-glucosamine + 6-O-methyl-Manalpha6(Manalpha3)Man-beta-octyl
-
 Rattus norvegicus UDP + ?
-
 ?
2.4.1.101 UDP-N-acetyl-D-glucosamine + Man3Man-O-beta4-N-acetyl-D-glucosamine
-
 Rattus norvegicus UDP + ?
-
 ?
2.4.1.101 UDP-N-acetyl-D-glucosamine + Manalpha6(4-deoxy-Manalpha3)Man-beta-octyl
-
 Rattus norvegicus UDP + ?
-
 ?
2.4.1.101 UDP-N-acetyl-D-glucosamine + Manalpha6(4-O-(5-iodoacetamidopentyl)-Manalpha3)Man-beta-octyl
-
 Rattus norvegicus UDP + ?
-
 ?
2.4.1.101 UDP-N-acetyl-D-glucosamine + Manalpha6(4-O-methyl-Manalpha3)Man-beta-octyl
-
 Rattus norvegicus UDP + ?
-
 ?
2.4.1.101 UDP-N-acetyl-D-glucosamine + Manalpha6(Manalpha3)Man-O-beta hexyl
-
 Rattus norvegicus UDP + ?
-
 ?
2.4.1.101 UDP-N-acetyl-D-glucosamine + Manalpha6(Manalpha3)Man-O-beta(8-methoxycarbonyl)octyl
-
 Rattus norvegicus UDP + ?
-
 ?
2.4.1.101 UDP-N-acetyl-D-glucosamine + Manalpha6(Manalpha3)Man-O-beta-octyl
-
 Rattus norvegicus UDP + ?
-
 ?
2.4.1.101 UDP-N-acetyl-D-glucosamine + Manalpha6(Manalpha3)Man-O-beta4-N-acetyl-D-glucosamine
-
 Rattus norvegicus UDP + ?
-
 ?
2.4.1.101 UDP-N-acetyl-D-glucosamine + Manalpha6(Manalpha3)Man-O-beta4-N-acetyl-D-glucosamine-beta4(L-fucose-alpha6)-N-acetyl-D-glucosamine-Asn
-
 Rattus norvegicus UDP + ?
-
 ?
2.4.1.101 UDP-N-acetyl-D-glucosamine + Manalpha6(Manalpha3)Man-O-beta4-N-acetyl-D-glucosamine-beta4-N-acetyl-D-glucosamine
-
 Rattus norvegicus UDP + ?
-
 ?
2.4.1.101 UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosamine-beta2-Manalpha6(Manalpha3)Man-beta4-N-acetyl-D-glucosamine
-
 Rattus norvegicus UDP + ?
-
 ?
2.4.1.101 UDP-N-acetyl-D-glucosamine + R-Manalpha6(Manalpha3)Man-beta-octyl
-
 Rattus norvegicus UDP + ?
-
 ?
2.4.1.101 UDP-N-acetyl-D-glucosamine + [Manalpha(1-6)Manalpha(1-3)Manalpha(1-6)][Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-Asn
-
 Rattus norvegicus UDP + ?
-
 ?
2.4.1.143 UDP-N-acetyl-D-glucosamine + 3-deoxy-Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta-octyl
-
 Homo sapiens UDP + GlcNAcbeta(1-2)3-deoxy-Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta-octyl
-
 ?
2.4.1.143 UDP-N-acetyl-D-glucosamine + 3-O-methyl-Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta-octyl
-
 Homo sapiens UDP + GlcNAcbeta(1-2)3-O-methyl-Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta-octyl
-
 ?
2.4.1.143 UDP-N-acetyl-D-glucosamine + 4-deoxy-Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta-octyl
-
 Homo sapiens UDP + GlcNAcbeta(1-2)4-deoxy-Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta-octyl
-
 ?
2.4.1.143 UDP-N-acetyl-D-glucosamine + 4-O-methyl-Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta-octyl
-
 Homo sapiens UDP + GlcNAcbeta(1-2)4-O-methyl-Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta-octyl
-
 ?
2.4.1.143 UDP-N-acetyl-D-glucosamine + 6-deoxy-Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta-octyl
-
 Homo sapiens UDP + GlcNAcbeta(1-2)6-deoxy-Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta-octyl
-
 ?
2.4.1.143 UDP-N-acetyl-D-glucosamine + 6-O-methyl-Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta-octyl
-
 Homo sapiens UDP + GlcNAcbeta(1-2)6-O-methyl-Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta-octyl
-
 ?
2.4.1.143 UDP-N-acetyl-D-glucosamine + Manalpha(1-6)(GlcNAcbeta(1-2)-6-deoxy-Manalpha(1-3))Manbeta-octyl
-
 Homo sapiens UDP + GlcNAcbeta(1-2)Manalpha(1-6)(GlcNAcbeta(1-2)-6-deoxy-Manalpha(1-3))Manbeta-octyl
-
 ?
2.4.1.143 UDP-N-acetyl-D-glucosamine + Manalpha(1-6)(GlcNAcbeta(1-2)4-O-methyl-Manalpha(1-3))Manbeta-octyl
-
 Homo sapiens UDP + GlcNAcbeta(1-2)Manalpha(1-6)(GlcNAcbeta(1-2)4-O-methyl-Manalpha(1-3))Manbeta-octyl
-
 ?
2.4.1.143 UDP-N-acetyl-D-glucosamine + Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))-4-deoxy-Manbeta-octyl
-
 Homo sapiens UDP + GlcNAcbeta(1-2)Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))-4-deoxy-Manbeta-octyl
-
 ?
2.4.1.143 UDP-N-acetyl-D-glucosamine + Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta-octyl
-
 Homo sapiens UDP + GlcNAcbeta(1-2)Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta-octyl
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.101 N-acetylglucosaminyltransferases I
-
 Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.1.101 0.8
-
 Manalpha6(6-O-methyl-Manalpha3)Man-beta-octyl
-
 Rattus norvegicus
2.4.1.101 1.1
-
 Manalpha6(6-O-(4,4-azopentyl)-Manalpha3)Man-beta-octyl
-
 Rattus norvegicus
2.4.1.101 2.6
-
 Manalpha6(6-O-(4,5-epoxypentyl)-Manalpha3)Man-beta-octyl
-
 Rattus norvegicus
2.4.1.101 8.8
-
 Manalpha6(6-O-(4-oxopentyl)-Manalpha3)Man-beta-octyl
-
 Rattus norvegicus
2.4.1.101 10.2
-
 Manalpha6(6-O-(5-pentanolyl)-Manalpha3)Man-beta-octyl
-
 Rattus norvegicus
2.4.1.101 13
-
 [Manalpha6(Manalpha3)][4-O-methyl-Man]-beta4-N-acetyl-D-glucosamine
-
 Rattus norvegicus
2.4.1.143 0.13
-
 2-deoxy-Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Man-beta-octyl
-
 Homo sapiens
2.4.1.143 0.9
-
 GlcNAcbeta(1-2)Manalpha(1-3)Man-beta-octyl
-
 Homo sapiens
2.4.1.143 1
-
 3-O-(4,4-azopentyl)-Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Man-beta-octyl
-
 Homo sapiens
2.4.1.143 2.4
-
 3-O-pentyl-Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Man-beta-octyl
-
 Homo sapiens
2.4.1.143 2.5
-
 3-O-(5-aminopentyl)-Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Man-beta-octyl
-
 Homo sapiens