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Literature summary extracted from

  • Wittwer, C.T.; Wyse, B.W.; Hansen, R.G.
    Enzymic hydrolysis of pantetheine (1986), Methods Enzymol., 122, 36-43.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.5.1.92 dithioerythritol 1-13 mM, activates Sus scrofa

General Stability

EC Number General Stability Organism
3.5.1.92 after solubilization, the enzsme can be stored indefinitely in the frozen state without significant loss of activity Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.92 Hg2+
-
 Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.1.92 0.02
-
 (R)-pantetheine
-
 Sus scrofa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.5.1.92 54000
-
 gel filtration Sus scrofa
3.5.1.92 60000
-
 1 * 60000, SDS-PAGE Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.92 Sus scrofa
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.5.1.92 glycoprotein 11.8% carbohydrate by weight Sus scrofa

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.1.92
-
 Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.92 renal cortex
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.5.1.92 14
-
-
 Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.92 (R)-pantetheine + H2O
-
 Sus scrofa (R)-pantothenate + cysteamine
-
 ?
3.5.1.92 pantothenyl-beta-aminoethanol + H2O
-
 Sus scrofa ?
-
 ?
3.5.1.92 S-ethylpantetheine + H2O
-
 Sus scrofa ?
-
 ?
3.5.1.92 S-pantetheine 3-pyruvate + H2O
-
 Sus scrofa S-cysteamine 3-pyruvate + pantothenate S-cysteamine 3-pyruvate spontaneously forms a cyclic product ?

Subunits

EC Number Subunits Comment Organism
3.5.1.92 monomer 1 * 60000, SDS-PAGE Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.1.92 9 9.5
-
 Sus scrofa