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Literature summary extracted from

  • Myllyharju, J.
    Prolyl 4-hydroxylases, the key enzymes of collagen biosynthesis (2003), Matrix Biol., 22, 15-24.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.11.2 ascorbate required for activity Drosophila melanogaster
1.14.11.2 ascorbate required for activity Arabidopsis thaliana
1.14.11.2 ascorbate required for activity Paramecium bursaria Chlorella virus-1
1.14.11.2 ascorbate required for activity Homo sapiens
1.14.11.2 ascorbate required for activity Caenorhabditis elegans

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.11.2 poly(L-proline)
-
 Drosophila melanogaster
1.14.11.2 poly(L-proline)
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.11.2 0.0002
-
 poly(L-proline) molecular weight 20000-40000 Da Arabidopsis thaliana
1.14.11.2 0.0004
-
 Fe2+
-
 Paramecium bursaria Chlorella virus-1
1.14.11.2 0.002
-
 Fe2+
-
 Caenorhabditis elegans
1.14.11.2 0.002
-
 poly(L-proline) molecular weight 5000-10000 Da Arabidopsis thaliana
1.14.11.2 0.003
-
 Fe2+
-
 Drosophila melanogaster
1.14.11.2 0.004
-
 Fe2+
-
 Homo sapiens
1.14.11.2 0.006
-
 Fe2+
-
 Homo sapiens
1.14.11.2 0.016
-
 Fe2+
-
 Arabidopsis thaliana
1.14.11.2 0.018
-
 (L-Pro-L-Pro-Gly)10
-
 Drosophila melanogaster
1.14.11.2 0.018
-
 (L-Pro-L-Pro-Gly)10
-
 Homo sapiens
1.14.11.2 0.02
-
 2-oxoglutarate
-
 Paramecium bursaria Chlorella virus-1
1.14.11.2 0.02
-
 (L-Pro-L-Pro-Gly)10
-
 Caenorhabditis elegans
1.14.11.2 0.022
-
 2-oxoglutarate
-
 Homo sapiens
1.14.11.2 0.06
-
 (L-Pro-L-Pro-Gly)10
-
 Arabidopsis thaliana
1.14.11.2 0.08
-
 2-oxoglutarate
-
 Caenorhabditis elegans
1.14.11.2 0.084
-
 2-oxoglutarate
-
 Drosophila melanogaster
1.14.11.2 0.095
-
 (L-Pro-L-Pro-Gly)10
-
 Homo sapiens
1.14.11.2 0.1
-
 poly(L-proline) molecular weight 20000-40000 Da Paramecium bursaria Chlorella virus-1
1.14.11.2 0.13
-
 2-oxoglutarate
-
 Arabidopsis thaliana
1.14.11.2 0.3
-
 ascorbate
-
 Drosophila melanogaster
1.14.11.2 0.3
-
 ascorbate
-
 Arabidopsis thaliana
1.14.11.2 0.3
-
 ascorbate
-
 Paramecium bursaria Chlorella virus-1
1.14.11.2 0.33
-
 ascorbate
-
 Homo sapiens
1.14.11.2 0.34
-
 ascorbate
-
 Homo sapiens
1.14.11.2 0.35
-
 ascorbate
-
 Caenorhabditis elegans
1.14.11.2 2.9
-
 (L-Pro-L-Pro-Gly)10
-
 Paramecium bursaria Chlorella virus-1

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.11.2 Fe2+ required for activity Drosophila melanogaster
1.14.11.2 Fe2+ required for activity Arabidopsis thaliana
1.14.11.2 Fe2+ required for activity Paramecium bursaria Chlorella virus-1
1.14.11.2 Fe2+ required for activity Homo sapiens
1.14.11.2 Fe2+ required for activity Caenorhabditis elegans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.11.2 procollagen L-proline + 2-oxoglutarate + O2 Drosophila melanogaster
-
 procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
1.14.11.2 procollagen L-proline + 2-oxoglutarate + O2 Arabidopsis thaliana
-
 procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
1.14.11.2 procollagen L-proline + 2-oxoglutarate + O2 Paramecium bursaria Chlorella virus-1
-
 procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
1.14.11.2 procollagen L-proline + 2-oxoglutarate + O2 Homo sapiens
-
 procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
1.14.11.2 procollagen L-proline + 2-oxoglutarate + O2 Caenorhabditis elegans
-
 procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.2 Arabidopsis thaliana
-
-
-
1.14.11.2 Caenorhabditis elegans Q20065 alpha-2 subunit
-
1.14.11.2 Drosophila melanogaster
-
-
-
1.14.11.2 Homo sapiens O15460 alpha-subunit
-
1.14.11.2 Homo sapiens P13674 alpha-subunit
-
1.14.11.2 Paramecium bursaria Chlorella virus-1
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.2 (L-Pro-L-Pro-Gly)10 + 2-oxoglutarate + O2
-
 Drosophila melanogaster (L-Pro-L-Pro-Gly)10-trans-4-hydroxy-L-proline + succinate + CO2
-
 r
1.14.11.2 (L-Pro-L-Pro-Gly)10 + 2-oxoglutarate + O2
-
 Arabidopsis thaliana (L-Pro-L-Pro-Gly)10-trans-4-hydroxy-L-proline + succinate + CO2
-
 r
1.14.11.2 (L-Pro-L-Pro-Gly)10 + 2-oxoglutarate + O2
-
 Paramecium bursaria Chlorella virus-1 (L-Pro-L-Pro-Gly)10-trans-4-hydroxy-L-proline + succinate + CO2
-
 r
1.14.11.2 (L-Pro-L-Pro-Gly)10 + 2-oxoglutarate + O2
-
 Homo sapiens (L-Pro-L-Pro-Gly)10-trans-4-hydroxy-L-proline + succinate + CO2
-
 r
1.14.11.2 (L-Pro-L-Pro-Gly)10 + 2-oxoglutarate + O2
-
 Caenorhabditis elegans (L-Pro-L-Pro-Gly)10-trans-4-hydroxy-L-proline + succinate + CO2
-
 r
1.14.11.2 (Pro-Pro-Gly)10 L-proline + 2-oxoglutarate + O2
-
 Drosophila melanogaster (Pro-Pro-Gly)10 trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
1.14.11.2 (Pro-Pro-Gly)10 L-proline + 2-oxoglutarate + O2
-
 Arabidopsis thaliana (Pro-Pro-Gly)10 trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
1.14.11.2 (Pro-Pro-Gly)10 L-proline + 2-oxoglutarate + O2
-
 Paramecium bursaria Chlorella virus-1 (Pro-Pro-Gly)10 trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
1.14.11.2 (Pro-Pro-Gly)10 L-proline + 2-oxoglutarate + O2
-
 Homo sapiens (Pro-Pro-Gly)10 trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
1.14.11.2 (Pro-Pro-Gly)10 L-proline + 2-oxoglutarate + O2
-
 Caenorhabditis elegans (Pro-Pro-Gly)10 trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
1.14.11.2 2-oxoglutarate + O2 + ascorbate
-
 Drosophila melanogaster succinate + dehydroascorbate + CO2 + H2O
-
 ?
1.14.11.2 2-oxoglutarate + O2 + ascorbate
-
 Arabidopsis thaliana succinate + dehydroascorbate + CO2 + H2O
-
 ?
1.14.11.2 2-oxoglutarate + O2 + ascorbate
-
 Paramecium bursaria Chlorella virus-1 succinate + dehydroascorbate + CO2 + H2O
-
 ?
1.14.11.2 2-oxoglutarate + O2 + ascorbate
-
 Homo sapiens succinate + dehydroascorbate + CO2 + H2O
-
 ?
1.14.11.2 2-oxoglutarate + O2 + ascorbate
-
 Caenorhabditis elegans succinate + dehydroascorbate + CO2 + H2O
-
 ?
1.14.11.2 poly(L-proline) + 2-oxoglutarate + O2
-
 Paramecium bursaria Chlorella virus-1 poly trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
1.14.11.2 poly(L-proline) + 2-oxoglutarate + O2
-
 Arabidopsis thaliana poly(trans-4-hydroxy-L-proline) + succinate + CO2
-
 r
1.14.11.2 procollagen L-proline + 2-oxoglutarate + O2
-
 Drosophila melanogaster procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
1.14.11.2 procollagen L-proline + 2-oxoglutarate + O2
-
 Arabidopsis thaliana procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
1.14.11.2 procollagen L-proline + 2-oxoglutarate + O2
-
 Paramecium bursaria Chlorella virus-1 procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
1.14.11.2 procollagen L-proline + 2-oxoglutarate + O2
-
 Homo sapiens procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
1.14.11.2 procollagen L-proline + 2-oxoglutarate + O2
-
 Caenorhabditis elegans procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
1.14.11.2 tetramer
-
 Drosophila melanogaster
1.14.11.2 tetramer
-
 Arabidopsis thaliana
1.14.11.2 tetramer
-
 Paramecium bursaria Chlorella virus-1
1.14.11.2 tetramer
-
 Homo sapiens
1.14.11.2 tetramer
-
 Caenorhabditis elegans

Synonyms

EC Number Synonyms Comment Organism
1.14.11.2 AT-P4H-1
-
 Arabidopsis thaliana
1.14.11.2 CePHY-1/PHY-2/PDI2
-
 Caenorhabditis elegans
1.14.11.2 DmP4H
-
 Drosophila melanogaster
1.14.11.2 HuPH4-I
-
 Homo sapiens
1.14.11.2 HuPH4-II
-
 Homo sapiens
1.14.11.2 PBCV-1 P4H
-
 Paramecium bursaria Chlorella virus-1

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.11.2 0.00002
-
 poly(L-proline) molecular weight 20000-40000 Da Homo sapiens
1.14.11.2 0.0005
-
 poly(L-proline) molecular weight 5000-10000 Da Homo sapiens
1.14.11.2 0.003
-
 poly(L-proline) molecular weight 20000-40000 Da Drosophila melanogaster
1.14.11.2 0.018
-
 poly(L-proline) molecular weight 5000-10000 Da Drosophila melanogaster
1.14.11.2 0.02
-
 poly(L-proline) molecular weight 20000-40000 Da Homo sapiens
1.14.11.2 0.095
-
 poly(L-proline) molecular weight 5000-10000 Da Homo sapiens