EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.14.14.23 | dithiothreitol | - |
Homo sapiens |
EC Number | General Stability | Organism |
---|---|---|
1.14.14.23 | rapid inactivation upon incubating microsomes with NADPH, half-life: 1 h, addition of dithiothreitol partially protects against inactivation | Homo sapiens |
1.14.14.23 | rapid inactivation upon incubating microsomes with NADPH, half-life: 1 h, addition of dithiothreitol partially protects against inactivation | Rattus norvegicus |
1.14.14.23 | rapid inactivation upon incubating microsomes with NADPH, half-life: 1 h, addition of dithiothreitol partially protects against inactivation | Oryctolagus cuniculus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.14.14.23 | microsome | - |
Homo sapiens | - |
- |
1.14.14.23 | microsome | - |
Oryctolagus cuniculus | - |
- |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.14.14.23 | 58000 | - |
x * 58000, SDS-PAGE | Homo sapiens |
1.14.14.23 | 58000 | - |
x * 58000, SDS-PAGE | Rattus norvegicus |
1.14.14.23 | 58000 | - |
x * 58000, SDS-PAGE | Oryctolagus cuniculus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.14.23 | cholesterol + [reduced NADPH-hemoprotein reductase] + O2 | Homo sapiens | first step of cholesterol catabolism | 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
1.14.14.23 | cholesterol + [reduced NADPH-hemoprotein reductase] + O2 | Rattus norvegicus | first step of cholesterol catabolism | 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
1.14.14.23 | cholesterol + [reduced NADPH-hemoprotein reductase] + O2 | Oryctolagus cuniculus | first step of cholesterol catabolism | 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.14.23 | Homo sapiens | - |
- |
- |
1.14.14.23 | Oryctolagus cuniculus | - |
- |
- |
1.14.14.23 | Rattus norvegicus | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.14.23 | cholesterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
1.14.14.23 | cholesterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Rattus norvegicus | 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
1.14.14.23 | cholesterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Oryctolagus cuniculus | 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
1.14.14.23 | cholesterol + [reduced NADPH-hemoprotein reductase] + O2 | first step of cholesterol catabolism | Homo sapiens | 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
1.14.14.23 | cholesterol + [reduced NADPH-hemoprotein reductase] + O2 | first step of cholesterol catabolism | Rattus norvegicus | 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
1.14.14.23 | cholesterol + [reduced NADPH-hemoprotein reductase] + O2 | first step of cholesterol catabolism | Oryctolagus cuniculus | 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.14.14.23 | ? | x * 58000, SDS-PAGE | Homo sapiens |
1.14.14.23 | ? | x * 58000, SDS-PAGE | Rattus norvegicus |
1.14.14.23 | ? | x * 58000, SDS-PAGE | Oryctolagus cuniculus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.14.14.23 | NADPH | - |
Homo sapiens | |
1.14.14.23 | NADPH | - |
Rattus norvegicus | |
1.14.14.23 | NADPH | - |
Oryctolagus cuniculus |