Literature summary extracted from

Maggioli, G.; Piacenza, L.; Carambula, B.; Carmona, C.
Purification, characterization, and immunolocalization of a thioredoxin reductase from adult (2004), J. Parasitol., 90, 205-211.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
1.8.1.9	FADH2	activates	Fasciola hepatica

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.8.1.9	aurothioglucose	IC50: 120 nM	Fasciola hepatica

Metals/Ions

EC Number	Metals/Ions	Comment	Organism	Structure
1.8.1.9	selenium	selenoenzyme	Fasciola hepatica

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.8.1.9	Fasciola hepatica	-	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
1.8.1.9	-	Fasciola hepatica

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.8.1.9	additional information	not found in tegument of adult fluke	Fasciola hepatica	-
1.8.1.9	parenchyma	-	Fasciola hepatica	-
1.8.1.9	testis	-	Fasciola hepatica	-

Specific Activity [micromol/min/mg]

EC Number	Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
1.8.1.9	additional information	-	-	Fasciola hepatica

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.8.1.9	5,5'-dithiobis(2-nitrobenzoic acid) + NADPH	-	Fasciola hepatica	2-nitro-5-thiobenzoate + NADP+	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.8.1.9	TrxR	-	Fasciola hepatica

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.8.1.9	NADPH	-	Fasciola hepatica

IC50 Value

EC Number	IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
1.8.1.9	0.00012	-	IC50: 120 nM	Fasciola hepatica	aurothioglucose

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Release 2023.1 (January 2023)