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Literature summary extracted from

  • McKinney, J.; Knappskog, P.M.; Haavik, J.
    Different properties of the central and peripheral forms of human tryptophan hydroxylase (2005), J. Neurochem., 92, 311-320.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.16.4 TPH1, expression in Escherichia coli Homo sapiens
1.14.16.4 TPH2, expression in Escherichia coli Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.16.4 (6R)-L-erytho-5,6,7,8-tetrahydrobiopterin TPH2, substrate inhibition Homo sapiens
1.14.16.4 L-tryptophan TPH2, substrate inhibition Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.16.4 0.0106
-
 L-tryptophan TPH1 fusion protein with maltose-binding protein Homo sapiens
1.14.16.4 0.0128
-
 (6R)-L-erytho-5,6,7,8-tetrahydrobiopterin TPH2 fusion protein with maltose-binding protein Homo sapiens
1.14.16.4 0.0131
-
 L-tryptophan TPH2, in vitro transcription and translation product Homo sapiens
1.14.16.4 0.0202
-
 (6R)-L-erytho-5,6,7,8-tetrahydrobiopterin TPH2 Homo sapiens
1.14.16.4 0.0228
-
 L-tryptophan TPH1 Homo sapiens
1.14.16.4 0.027
-
 (6R)-L-erytho-5,6,7,8-tetrahydrobiopterin TPH1 fusion protein with maltose-binding protein Homo sapiens
1.14.16.4 0.039
-
 (6R)-L-erytho-5,6,7,8-tetrahydrobiopterin TPH1 Homo sapiens
1.14.16.4 0.0403
-
 L-tryptophan TPH2 Homo sapiens
1.14.16.4 0.0434
-
 L-tryptophan TPH2 fusion protein with maltose-binding protein Homo sapiens
1.14.16.4 0.111
-
 L-tryptophan TPH1. in vitro transcription and translation product Homo sapiens
1.14.16.4 0.146
-
 (6R)-L-erytho-5,6,7,8-tetrahydrobiopterin TPH1, in vitro transcription and translation product Homo sapiens
1.14.16.4 0.281
-
 (6R)-L-erytho-5,6,7,8-tetrahydrobiopterin TPH2, in vitro transcription and translation product Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.14.16.4 58500
-
 4 * 58500, TPH1 Homo sapiens
1.14.16.4 68500
-
 4 * 68500, TPH2 Homo sapiens
1.14.16.4 234000
-
 TPH1, gel filtration Homo sapiens
1.14.16.4 274000
-
 TPH2, gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.16.4 L-tryptophan + tetrahydropteridine + O2 Homo sapiens rate-limiting step in biosynthesis of serotonin in brain 5-hydroxy-L-tryptophan + dihydropteridine + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.16.4 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.14.16.4 phosphoprotein TPH1 is phosphorylated by cAMP-dependent protein kinase A Homo sapiens
1.14.16.4 phosphoprotein TPH2 is phosphorylated by cAMP-dependent protein kinase A Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.16.4 brain
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.16.4 L-tryptophan + (6R)-L-erytho-5,6,7,8-tetrahydrobiopterin + O2
-
 Homo sapiens 5-hydroxy-L-tryptophan + ?
-
 ?
1.14.16.4 L-tryptophan + tetrahydropteridine + O2 rate-limiting step in biosynthesis of serotonin in brain Homo sapiens 5-hydroxy-L-tryptophan + dihydropteridine + H2O
-
 ?

Subunits

EC Number Subunits Comment Organism
1.14.16.4 tetramer 4 * 58500, TPH1 Homo sapiens
1.14.16.4 tetramer 4 * 68500, TPH2 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.14.16.4 TPH1
-
 Homo sapiens
1.14.16.4 TPH2
-
 Homo sapiens