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Literature summary extracted from

  • Chaube, R.; Joy, K.P.
    Thyroid hormone modulation of brain in vivo tyrosine hydroxylase activity and kinetics in the female catfish Heteropneustes fossilis (2003), J. Endocrinol., 179, 205-215.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.16.2 thyroxine stimulatory effect is due to increased affinity of the enzyme for its cofactor 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydropteridine Heteropneustes fossilis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.16.2 additional information Heteropneustes fossilis the brain enzyme is sensitive to the thyroid status. Hormone excess activates and deficiency retards the enzyme activity by midifying its kinetic function ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.16.2 Heteropneustes fossilis
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.16.2 brain
-
 Heteropneustes fossilis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.16.2 L-tyrosine + 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydropteridine + O2
-
 Heteropneustes fossilis ?
-
 ?
1.14.16.2 additional information the brain enzyme is sensitive to the thyroid status. Hormone excess activates and deficiency retards the enzyme activity by midifying its kinetic function Heteropneustes fossilis ?
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.16.2 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydropteridine
-
 Heteropneustes fossilis