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Literature summary extracted from

  • Huang, S.A.; Dorfman, D.M.; Genest, D.R.; Salvatore, D.; Larsen, P.R.
    Type 3 iodothyronine deiodinase is highly expressed in the human uteroplacental unit and in fetal epithelium (2003), J. Clin. Endocrinol. Metab., 88, 1384-1388.
    View publication on PubMed

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.21.99.3 Se selenoenzyme Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.21.99.3 additional information Homo sapiens the enzyme is the major physiological inactivator of thyroid hormone. The presence of the enzyme at maternal-fetal interfaces is consistent with its role in modulating the thyroid status of the human fetus and its expression in endometrium suggests that local regulation of thyroid status is important in implantation ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.21.99.3 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.21.99.3 colonic epithelium fetal Homo sapiens
-
1.21.99.3 cytotrophoblast
-
Homo sapiens
-
1.21.99.3 decidua
-
Homo sapiens
-
1.21.99.3 endothelium of fetal vessels Homo sapiens
-
1.21.99.3 respiratory epithelium fetal Homo sapiens
-
1.21.99.3 syncytiotrophoblast
-
Homo sapiens
-
1.21.99.3 umbilical artery
-
Homo sapiens
-
1.21.99.3 umbilical vein
-
Homo sapiens
-
1.21.99.3 urinary tract epithelium Homo sapiens
-
1.21.99.3 uterine endometrium of nonpregnant human uteri Homo sapiens
-
1.21.99.3 uterus endometrial gland Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.99.3 3,3',5'-triido-L-thyronine + AH
-
Homo sapiens 3,3'-diiodothyronine + iodide + A + H+
-
?
1.21.99.3 L-thyroxine + AH2
-
Homo sapiens 3,3',5'-triido-L-thyronine + iodide + A + H+
-
?
1.21.99.3 additional information the enzyme is the major physiological inactivator of thyroid hormone. The presence of the enzyme at maternal-fetal interfaces is consistent with its role in modulating the thyroid status of the human fetus and its expression in endometrium suggests that local regulation of thyroid status is important in implantation Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
1.21.99.3 type 3 iodothyronine deiodinase
-
Homo sapiens