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Literature summary extracted from

  • Eyles, D.W.; Smith, S.; Kinobe, R.; Hewison, M.; McGrath, J.J.
    Distribution of the vitamin D receptor and 1alpha-hydroxylase in human brain (2005), J. Chem. Neuroanat., 29, 21-30.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.15.18 cytoplasm
-
 Homo sapiens 5737
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.15.18 25-hydroxyvitamin D3 + NADPH + O2 Homo sapiens final step of the activation of vitamin D 1alpha,25-dihydroxyvitamin D3 + NADP+ + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.15.18 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.15.18 brain distributed throughout all brain regions, neurons and glial cells Homo sapiens
-
1.14.15.18 hypothalamus high enzyme level Homo sapiens
-
1.14.15.18 kidney
-
 Homo sapiens
-
1.14.15.18 substantia nigra high enzyme level in large dopaminergic neurons Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.15.18 25-hydroxyvitamin D3 + NADPH + O2
-
 Homo sapiens 1alpha,25-dihydroxyvitamin D3 + NADP+ + H2O
-
 ?
1.14.15.18 25-hydroxyvitamin D3 + NADPH + O2 final step of the activation of vitamin D Homo sapiens 1alpha,25-dihydroxyvitamin D3 + NADP+ + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.15.18 25-hydroxyvitamin D-1alpha-hydroxylase
-
 Homo sapiens