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Literature summary extracted from

  • Kobayashi, K.; Yoshioka, S.; Kato, Y.; Asano, Y.; Aono, S.
    Regulation of aldoxime dehydratase activity by redox-dependent change in the coordination structure of the aldoxime-heme complex (2005), J. Biol. Chem., 280, 5486-5490.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
4.8.1.4 H306A very low activity, substrate is bound to ferrous heme Bacillus sp. (in: Bacteria)

Organism

EC Number Organism UniProt Comment Textmining
4.8.1.4 Bacillus sp. (in: Bacteria)
-
-
-
4.8.1.4 Bacillus sp. (in: Bacteria) OxB-1
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
4.8.1.4 (Z)-phenylacetaldehyde oxime = phenylacetonitrile + H2O oxidation state of heme controls the coordination structure of a substrate-hem complex, which regulates enzyme activity Bacillus sp. (in: Bacteria)
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.8.1.4 (Z)-phenylacetaldehyde oxime
-
 Bacillus sp. (in: Bacteria) phenylacetonitrile + H2O
-
 ?
4.8.1.4 (Z)-phenylacetaldehyde oxime
-
 Bacillus sp. (in: Bacteria) OxB-1 phenylacetonitrile + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.8.1.4 OxdB
-
 Bacillus sp. (in: Bacteria)

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.8.1.4 7 8
-
 Bacillus sp. (in: Bacteria)

pH Range

EC Number pH Minimum pH Maximum Comment Organism
4.8.1.4 7 8
-
 Bacillus sp. (in: Bacteria)

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
4.8.1.4 6
-
 denaturation below Bacillus sp. (in: Bacteria)
4.8.1.4 10
-
 denaturation above Bacillus sp. (in: Bacteria)

Cofactor

EC Number Cofactor Comment Organism Structure
4.8.1.4 heme active state contains ferrous heme Bacillus sp. (in: Bacteria)
4.8.1.4 heme both the Fe(II) and Fe(III) hemes in OxdB bind the substrate, (Z)-phenylacetaldehyde oxime, using a different coordination mode. Ferrous OxdB is active, but ferric OxdB is not Bacillus sp. (in: Bacteria)