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Literature summary extracted from

  • Rilla, K.; Siiskonen, H.; Spicer, A.P.; Hyttinen, J.M.; Tammi, M.I.; Tammi, R.H.
    Plasma membrane residence of hyaluronan synthase is coupled to its enzymatic activity (2005), J. Biol. Chem., 280, 31890-31897.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.212 functional expression of isozymes HAS2 and HAS3 in rat epidermal keratinocytes as N-terminally GFP-tagged protein, recombinant isozymes GFP-HAS2 and GFP-HAS3 travel through endoplasmic reticulum, Golgi, plasma membrne, and endocytic vesicles, expression of inactive GFP-tagged HAS3 D216A mutant and of GFP-tagged HAS3-deletion mutants in keratinocytes Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
2.4.1.212 D216A site-directed mutagenesis, isozyme HAS3, inactive mutant Mus musculus
2.4.1.212 additional information construction of deletion mutants of isozyme HAS3 Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.212 4-Methylumbelliferone changes the localization of the enzyme by preventing its association with the plasma membrane Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.212 endocytic vesicle
-
 Mus musculus 30139
-
2.4.1.212 endoplasmic reticulum
-
 Mus musculus 5783
-
2.4.1.212 Golgi apparatus
-
 Mus musculus 5794
-
2.4.1.212 additional information recombinant isozymes GFP-HAS2 and GFP-HAS3 travel through endoplasmic reticulum, Golgi, plasma membrane, and endocytic vesicles in keratinocytes Mus musculus
-
-
2.4.1.212 plasma membrane integral, plasma membrane residence of hyaluronan synthase is coupled to its enzymatic activity Mus musculus 5886
-

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.212 Mus musculus
-
 isozymes HAS2 and HAS3
-

Synonyms

EC Number Synonyms Comment Organism
2.4.1.212 HAS
-
 Mus musculus