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Literature summary extracted from

  • Verbsky, J.W.; Chang, S.C.; Wilson, M.P.; Mochizuki, Y.; Majerus, P.W.
    The pathway for the production of inositol hexakisphosphate in human cells (2005), J. Biol. Chem., 280, 1911-1920.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.1.140 synthesis overexpression of enzyme does not increase the level of inositolpentakisphosphate, gene silencing of enzyme results in decreased inositol pentakisphosphate and inositol hexakisphosphate levels Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.159 stable overexpression in HEK-293 cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.140 additional information gene silencing of enzyme results in decreased inositol pentakisphosphate and inositol hexakisphosphate levels Homo sapiens
2.7.1.159 additional information enzyme silencing in HeLa cells decreases the levels of inositol pentakisphosphate and inositol hexakisphosphate, while overexpression in HEK-293 cells increases the levels of InsP4, InsP5, and InsP6, overview Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.159 KCl
-
 Homo sapiens
2.7.1.159 Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.159 additional information Homo sapiens regulation of enzymes involved in the inositol phosphate metabolism in human cells, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.140 Homo sapiens
-
 expression in HEK-293 cells
-
2.7.1.159 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.159 HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.159 ATP + 1D-myo-inositol-1,3,4,6-tetrakisphosphate
-
 Homo sapiens ADP + 1D-myo-inositol-1,3,4,5,6-pentakisphosphate
-
 ?
2.7.1.159 additional information regulation of enzymes involved in the inositol phosphate metabolism in human cells, overview Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.140 Ins(1,3,4,6)P4 5-kinase
-
 Homo sapiens
2.7.1.159 Ins(1,3,4)P3 5/6-kinase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.1.159 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.159 7.2
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.159 ATP
-
 Homo sapiens