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Literature summary extracted from

  • Pessi, G.; Choi, J.Y.; Reynolds, J.M.; Voelker, D.R.; Mamoun, C.B.
    In vivo evidence for the specificity of Plasmodium falciparum phosphoethanolamine methyltransferase and its coupling to the Kennedy pathway (2005), J. Biol. Chem., 280, 12461-12466.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.103 expression in Saccharomyces cerevisiae Plasmodium falciparum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.103 additional information Plasmodium falciparum enzyme is directly coupled to the Kennedy pathway for the de novo synthesis of phosphatidylcholine ?
-
 ?
2.1.1.103 S-adenosyl-L-methionine + ethanolamine phosphate Plasmodium falciparum the enzyme plays an important role in the biosynthetic pathway of phosphatidylcholine by providing the precursor phosphocholine via a three step S-adenosyl-L-methionine-dependent methylation of phosphoethanolamine. The enzyme function is directly coupled to the Kennedy pathway S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.103 Plasmodium falciparum
-
-
-
2.1.1.103 Plasmodium falciparum Q6T755 expression in Saccharomyces cerevisiae
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.103 additional information enzyme is directly coupled to the Kennedy pathway for the de novo synthesis of phosphatidylcholine Plasmodium falciparum ?
-
 ?
2.1.1.103 additional information no substrate: phosphatidyl ethanolamine Plasmodium falciparum ?
-
 ?
2.1.1.103 S-adenosyl-L-methionine + ethanolamine phosphate
-
 Plasmodium falciparum S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
 ?
2.1.1.103 S-adenosyl-L-methionine + ethanolamine phosphate the enzyme plays an important role in the biosynthetic pathway of phosphatidylcholine by providing the precursor phosphocholine via a three step S-adenosyl-L-methionine-dependent methylation of phosphoethanolamine. The enzyme function is directly coupled to the Kennedy pathway Plasmodium falciparum S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.103 Pfpmt
-
 Plasmodium falciparum