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Literature summary extracted from

  • Chang, T.S.; Jeong, W.; Woo, H.A.; Lee, S.M.; Park, S.; Rhee, S.G.
    Characterization of mammalian sulfiredoxin and its reactivation of hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteine (2004), J. Biol. Chem., 279, 50994-51001.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.8.98.2 expression in Escherichia coli Mus musculus
1.8.98.2 expression in Escherichia coli Homo sapiens
1.8.98.2 expression in Escherichia coli Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.8.98.2 0.0012
-
thioredoxin 1
-
Homo sapiens
1.8.98.2 0.03
-
ATP
-
Homo sapiens
1.8.98.2 1.8
-
GSH
-
Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.8.98.2 cytosol
-
Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.98.2 peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH Homo sapiens Srx is largely responsible for reduction of the Cys-SO2H of peroxiredoxin in A549 human cells peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.8.98.2 Homo sapiens
-
-
-
1.8.98.2 Mus musculus
-
-
-
1.8.98.2 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.8.98.2
-
Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.98.2 A-549 cell
-
Homo sapiens
-
1.8.98.2 HeLa cell
-
Homo sapiens
-
1.8.98.2 kidney
-
Homo sapiens
-
1.8.98.2 lung
-
Homo sapiens
-
1.8.98.2 spleen
-
Homo sapiens
-
1.8.98.2 thymus
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.98.2 additional information no activity with CTP, UTP, dCTP, or dTTP Homo sapiens ?
-
?
1.8.98.2 peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH
-
Mus musculus peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R
-
?
1.8.98.2 peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH
-
Rattus norvegicus peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R
-
?
1.8.98.2 peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH Srx is largely responsible for reduction of the Cys-SO2H of peroxiredoxin in A549 human cells Homo sapiens peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R
-
?
1.8.98.2 peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH both glutathione and thioredoxin are potential physiological electron donors Homo sapiens peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R
-
?
1.8.98.2 peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + GSH
-
Homo sapiens peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + GSSG
-
?
1.8.98.2 peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + thioredoxin 1
-
Homo sapiens peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + thioredoxin 1 disulfide
-
r
1.8.98.2 peroxiredoxin-(S-hydroxy-S-oxocysteine) + dATP + 2 R-SH both glutathione and thioredoxin are potential physiological electron donors Homo sapiens peroxiredoxin-(S-hydroxycysteine) + dADP + phosphate + R-S-S-R
-
?
1.8.98.2 peroxiredoxin-(S-hydroxy-S-oxocysteine) + dGTP + 2 R-SH both glutathione and thioredoxin are potential physiological electron donors Homo sapiens peroxiredoxin-(S-hydroxycysteine) + GDP + phosphate + R-S-S-R
-
?
1.8.98.2 peroxiredoxin-(S-hydroxy-S-oxocysteine) + GTP + 2 R-SH both glutathione and thioredoxin are potential physiological electron donors Homo sapiens peroxiredoxin-(S-hydroxycysteine) + GDP + phosphate + R-S-S-R
-
?

Synonyms

EC Number Synonyms Comment Organism
1.8.98.2 Srx
-
Mus musculus
1.8.98.2 Srx
-
Homo sapiens
1.8.98.2 Srx
-
Rattus norvegicus