EC Number | Application | Comment | Organism |
---|---|---|---|
2.1.2.3 | medicine | potential target for antineoplastic chemotherapy | Gallus gallus |
2.1.2.3 | medicine | potential target for antineoplastic chemotherapy | Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
2.1.2.3 | expressed in Escherichia coli BL21.DE3 as His-tag fusion protein | Gallus gallus |
2.1.2.3 | expressed in Escherichia coli BL21.DE3 as His-tag fusion protein | Homo sapiens |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
2.1.2.3 | crystallized in complex with its inhibitor 2-[5-hydroxy-3-methyl-1-(2-methyl-4-sulfophenyl)-1H-pyrazo]-4-sulfobenzoic acid | Gallus gallus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.1.2.3 | 2-[5-hydroxy-3-methyl-1-(2-methyl-4-sulfophenyl)-1H-pyrazo]-4-sulfobenzoic acid | Acid Yellow 54, 326203-A, competitive against 10-formyltetrahydrofolate, IC50: 0.012 mM, inhibitor partially blocks the cofactor binding site | Gallus gallus | |
2.1.2.3 | Acid Yellow 17 | IC50: 0.012 mM | Gallus gallus | |
2.1.2.3 | NCI324571-C | IC50: 0.042 mM | Gallus gallus | |
2.1.2.3 | NCI324572-F | IC50: 0.012 mM | Gallus gallus | |
2.1.2.3 | NCI3262203-A | IC50: 0.012 mM | Gallus gallus | |
2.1.2.3 | NCI47729-M | IC50: 0.003 mM | Gallus gallus | |
2.1.2.3 | SALOR2 | IC50: 0.0014 mM | Gallus gallus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.2.3 | 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazole-4-carboxamide | Gallus gallus | penultimate step of the purine de novo synthesis pathway | tetrahydrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazole-4-carboxamide | - |
? | |
2.1.2.3 | 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazole-4-carboxamide | Homo sapiens | penultimate step of the purine de novo synthesis pathway | tetrahydrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazole-4-carboxamide | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.2.3 | Gallus gallus | P31335 | - |
- |
2.1.2.3 | Homo sapiens | P31939 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.1.2.3 | recombinant protein using His-tag | Gallus gallus |
2.1.2.3 | recombinant protein using His-tag | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.2.3 | 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazole-4-carboxamide | - |
Gallus gallus | tetrahydrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazole-4-carboxamide | - |
? | |
2.1.2.3 | 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazole-4-carboxamide | - |
Homo sapiens | tetrahydrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazole-4-carboxamide | - |
? | |
2.1.2.3 | 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazole-4-carboxamide | penultimate step of the purine de novo synthesis pathway | Gallus gallus | tetrahydrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazole-4-carboxamide | - |
? | |
2.1.2.3 | 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazole-4-carboxamide | penultimate step of the purine de novo synthesis pathway | Homo sapiens | tetrahydrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazole-4-carboxamide | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.1.2.3 | AICAR transformylase/inosine monophosphate cyclohydrolase | bifunctional enzyme catalyzing the last two steps of the purine de novo synthesis pathway | Gallus gallus |
2.1.2.3 | AICAR transformylase/inosine monophosphate cyclohydrolase | bifunctional enzyme catalyzing the last two steps of the purine de novo synthesis pathway | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.1.2.3 | 10-formyltetrahydrofolate | - |
Gallus gallus | |
2.1.2.3 | 10-formyltetrahydrofolate | - |
Homo sapiens |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.1.2.3 | 0.007 | - |
2-[5-hydroxy-3-methyl-1-(2-methyl-4-sulfophenyl)-1H-pyrazo]-4-sulfobenzoic acid | pH 7.5 | Gallus gallus |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.1.2.3 | 0.0014 | - |
IC50: 0.0014 mM | Gallus gallus | SALOR2 | |
2.1.2.3 | 0.003 | - |
IC50: 0.003 mM | Gallus gallus | NCI47729-M | |
2.1.2.3 | 0.012 | - |
IC50: 0.012 mM | Gallus gallus | NCI3262203-A | |
2.1.2.3 | 0.012 | - |
IC50: 0.012 mM | Gallus gallus | NCI324572-F | |
2.1.2.3 | 0.012 | - |
IC50: 0.012 mM | Gallus gallus | Acid Yellow 17 | |
2.1.2.3 | 0.012 | - |
Acid Yellow 54, 326203-A, competitive against 10-formyltetrahydrofolate, IC50: 0.012 mM, inhibitor partially blocks the cofactor binding site | Gallus gallus | 2-[5-hydroxy-3-methyl-1-(2-methyl-4-sulfophenyl)-1H-pyrazo]-4-sulfobenzoic acid | |
2.1.2.3 | 0.042 | - |
IC50: 0.042 mM | Gallus gallus | NCI324571-C |