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Literature summary extracted from

  • Lambert, A.J.; Brand, M.D.
    Inhibitors of the quinone-binding site allow rapid superoxide production from mitochondrial NADH:ubiquinone oxidoreductase (complex I) (2004), J. Biol. Chem., 279, 39414-39420.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.2 mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.1.1.2 additional information Rattus norvegicus superoxide production rates by complex I during reverse electron transfer are much greater than during forwards electron transfer. The major site of superoxide production in complex I is the quinpone-binding site, it is most likely a semiquinone ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.2 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.1.1.2 skeletal muscle
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.2 additional information superoxide production rates by complex I during reverse electron transfer are much greater than during forwards electron transfer. The major site of superoxide production in complex I is the quinpone-binding site, it is most likely a semiquinone Rattus norvegicus ?
-
 ?
7.1.1.2 NADH + coenzyme Q2
-
 Rattus norvegicus NAD+ + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.1.1.2 complex I
-
 Rattus norvegicus
7.1.1.2 NADH:ubiquinone oxidoreductase
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
7.1.1.2 NADH
-
 Rattus norvegicus