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Literature summary extracted from

  • MacDonald, M.J.; Husain, R.D.; Hoffmann-Benning, S.; Baker, T.R.
    Immunochemical identification of coenzyme Q0-dihydrolipoamide adducts in the E2 components of the alpha-ketoglutarate and pyruvate dehydrogenase complexes partially explains the cellular toxicity of coenzyme Q0 (2004), J. Biol. Chem., 279, 27278-27285.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.61 coenzyme Q0 formation of coenzyme Q0-dihydrolipoamide adducts in the E2 components of the alpha-ketoglutarate complex (i.e. dihydrolipoamide succinyltransferase) partially explains the cellular toxicity of coenzyme Q0 Homo sapiens
2.3.1.61 coenzyme Q0 formation of coenzyme Q0-dihydrolipoamide adducts in the E2 components of the alpha-ketoglutarate complex (i.e. dihydrolipoamide succinyltransferase) partially explains the cellular toxicity of coenzyme Q0 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.61 mitochondrion
-
 Homo sapiens 5739
-
2.3.1.61 mitochondrion
-
 Rattus norvegicus 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.61 50000
-
 x * 50000, SDS-PAGE Homo sapiens
2.3.1.61 50000
-
 x * 50000, SDS-PAGE Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.61 Homo sapiens
-
-
-
2.3.1.61 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.61 adrenal gland
-
 Rattus norvegicus
-
2.3.1.61 brain
-
 Rattus norvegicus
-
2.3.1.61 heart
-
 Rattus norvegicus
-
2.3.1.61 kidney
-
 Rattus norvegicus
-
2.3.1.61 liver
-
 Rattus norvegicus
-
2.3.1.61 lung
-
 Rattus norvegicus
-
2.3.1.61 pancreatic islet
-
 Homo sapiens
-
2.3.1.61 pancreatic islet
-
 Rattus norvegicus
-
2.3.1.61 skeletal muscle
-
 Rattus norvegicus
-
2.3.1.61 spleen
-
 Rattus norvegicus
-

Subunits

EC Number Subunits Comment Organism
2.3.1.61 ? x * 50000, SDS-PAGE Homo sapiens
2.3.1.61 ? x * 50000, SDS-PAGE Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
2.3.1.61 dihydrolipoamide succinyltransferase
-
 Homo sapiens
2.3.1.61 dihydrolipoamide succinyltransferase
-
 Rattus norvegicus
2.3.1.61 E2 component of alpha-ketoglutarate dehydrogenase complex
-
 Homo sapiens
2.3.1.61 E2 component of alpha-ketoglutarate dehydrogenase complex
-
 Rattus norvegicus