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Literature summary extracted from

  • Rinehart, J.; Horn, E.K.; Wei, D.; Soll, D.; Schneider, A.
    Non-canonical eukaryotic glutaminyl- and glutamyl-tRNA synthetases form mitochondrial aminoacyl-tRNA in Trypanosoma brucei (2004), J. Biol. Chem., 279, 1161-1166.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.1.1.18
-
 Trypanosoma brucei

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.1.1.18 mitochondrion
-
 Trypanosoma brucei 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.1.17 ATP + L-glutamate + tRNAGlu Trypanosoma brucei eukaryotic-type discriminating glutamyl-tRNA synthetase, inability to utilize Escherichia coli tRNA as substrate. The enzyme is essential for growth of insect stage Trypanosoma brucei and is responsible for essentially all of the glutamyl-tRNA synthetase activity in cytosol and in mitochondria AMP + diphosphate + L-glutamyl-tRNAGlu
-
 ?
6.1.1.18 ATP + L-glutamine + tRNAGln Trypanosoma brucei
-
 AMP + diphosphate + L-glutaminyl-tRNAGln
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.17 Trypanosoma brucei
-
-
-
6.1.1.18 Trypanosoma brucei
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.1.1.18
-
 Trypanosoma brucei

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.17 ATP + L-glutamate + tRNAGlu eukaryotic-type discriminating glutamyl-tRNA synthetase, inability to utilize Escherichia coli tRNA as substrate. The enzyme is essential for growth of insect stage Trypanosoma brucei and is responsible for essentially all of the glutamyl-tRNA synthetase activity in cytosol and in mitochondria Trypanosoma brucei AMP + diphosphate + L-glutamyl-tRNAGlu
-
 ?
6.1.1.17 ATP + L-glutamate + tRNAGlu eukaryotic-type discriminating glutamyl-tRNA synthetase, inability to utilize Escherichia coli tRNA as substrate Trypanosoma brucei AMP + diphosphate + L-glutamyl-tRNAGlu
-
 ?
6.1.1.18 ATP + L-glutamine + tRNAGln
-
 Trypanosoma brucei AMP + diphosphate + L-glutaminyl-tRNAGln
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.1.1.17 GluRS
-
 Trypanosoma brucei
6.1.1.17 Glutamyl-tRNA synthetase
-
 Trypanosoma brucei