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Literature summary extracted from

  • Batten, M.L.; Imanishi, Y.; Maeda, T.; Tu, D.C.; Moise, A.R.; Bronson, D.; Possin, D.; Van Gelder, R.N.; Baehr, W.; Palczewski, K.
    Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver (2004), J. Biol. Chem., 279, 10422-10432.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.3.1.135 diagnostics the Lrat knockout mutant mice may serve as animal model with early onset severe retinal dystrophy and severe retinyl ester deprivation Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.135 gene Lrat, vector cloning for construction of knockout mutants Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.135 additional information gene Lrat disruption by targeted recombination for generation of a homozygous knockout mutant, the mutant mice develop normally, but the rod outer segments in the retina are about 35% shorter than those of wild-type mice, rod and cone visual functions are severely attenuated at an early age Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.135 phosphatidylcholine + all-trans-retinol-[cellular-retinol-binding-protein] Mus musculus lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters and the retinoid cycle in the eye and in the liver 2-acylglycerophosphocholine + all-trans-retinyl-ester-[cellular-retinol-binding-protein]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.135 Mus musculus
-
 gene Lrat
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.135 epithelium retinal, pigmented Mus musculus
-
2.3.1.135 liver
-
 Mus musculus
-
2.3.1.135 additional information determination of retinoid levels in liver, blood, and lung of wild-type and knockout mutant mice Mus musculus
-
2.3.1.135 retina pigmented epithelial cells Mus musculus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.135 phosphatidylcholine + all-trans-retinol-[cellular-retinol-binding-protein]
-
 Mus musculus 2-acylglycerophosphocholine + all-trans-retinyl-ester-[cellular-retinol-binding-protein]
-
 ?
2.3.1.135 phosphatidylcholine + all-trans-retinol-[cellular-retinol-binding-protein] lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters and the retinoid cycle in the eye and in the liver Mus musculus 2-acylglycerophosphocholine + all-trans-retinyl-ester-[cellular-retinol-binding-protein]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.135 lecithin-retinol acyltransferase
-
 Mus musculus
2.3.1.135 LRAT
-
 Mus musculus